Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

Sridharan Balu; Selvakumar Palanisamy; Vijaylakshmi Velusamy; Thomas C.K. Yang; El Said I. El-Shafey

doi:10.1016/j.msec.2019.110367

Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

Sridharan Balu, Selvakumar Palanisamy^*, Vijaylakshmi Velusamy, Thomas C.K. Yang, El Said I. El-Shafey

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

In the present work describes a facile synthesis of tin disulfide (SnS₂) nanorods decorated graphene-β-cyclodextrin (SnS₂/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS₂/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS₂/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS₂, and SnS₂/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS₂-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS₂/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM⁻¹ cm⁻²) along with reusability for detection of DA. The fabricated SnS₂/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.

Original language	English
Article number	110367
Pages (from-to)	110367
Journal	Materials Science and Engineering C
Volume	108
DOIs	https://doi.org/10.1016/j.msec.2019.110367
Publication status	Published - Mar 2020

Keywords

Biosensor
Dopamine
Graphene nanocomposite
Guest-host chemistry
SnS nanorods
Sonochemical method
Nanotubes/chemistry
Limit of Detection
Electrochemical Techniques
Oxidation-Reduction
Disulfides/chemistry
Humans
Dopamine/blood
Rats
beta-Cyclodextrins/chemistry
Graphite/chemistry
Tin/chemistry
Animals
X-Ray Diffraction
Biosensing Techniques
Nanocomposites/chemistry
Brain/metabolism

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.msec.2019.110367

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@article{2684641cad414f2ea9ed9e7e9b132bc1,

title = "Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum",

abstract = "In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.",

keywords = "Biosensor, Dopamine, Graphene nanocomposite, Guest-host chemistry, SnS nanorods, Sonochemical method, Nanotubes/chemistry, Limit of Detection, Electrochemical Techniques, Oxidation-Reduction, Disulfides/chemistry, Humans, Dopamine/blood, Rats, beta-Cyclodextrins/chemistry, Graphite/chemistry, Tin/chemistry, Animals, X-Ray Diffraction, Biosensing Techniques, Nanocomposites/chemistry, Brain/metabolism",

author = "Sridharan Balu and Selvakumar Palanisamy and Vijaylakshmi Velusamy and Yang, {Thomas C.K.} and El-Shafey, {El Said I.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2020",

month = mar,

doi = "10.1016/j.msec.2019.110367",

language = "English",

volume = "108",

pages = "110367",

journal = "Materials Science and Engineering C",

issn = "0928-4931",

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T1 - Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

AU - Balu, Sridharan

AU - Palanisamy, Selvakumar

AU - Velusamy, Vijaylakshmi

AU - Yang, Thomas C.K.

AU - El-Shafey, El Said I.

PY - 2020/3

Y1 - 2020/3

N2 - In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.

AB - In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.

KW - Biosensor

KW - Dopamine

KW - Graphene nanocomposite

KW - Guest-host chemistry

KW - SnS nanorods

KW - Sonochemical method

KW - Nanotubes/chemistry

KW - Limit of Detection

KW - Electrochemical Techniques

KW - Oxidation-Reduction

KW - Disulfides/chemistry

KW - Humans

KW - Dopamine/blood

KW - Rats

KW - beta-Cyclodextrins/chemistry

KW - Graphite/chemistry

KW - Tin/chemistry

KW - Animals

KW - X-Ray Diffraction

KW - Biosensing Techniques

KW - Nanocomposites/chemistry

KW - Brain/metabolism

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U2 - 10.1016/j.msec.2019.110367

DO - 10.1016/j.msec.2019.110367

M3 - Article

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AN - SCOPUS:85074996006

SN - 0928-4931

VL - 108

SP - 110367

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

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ER -

Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum

Abstract

Keywords

ASJC Scopus subject areas

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