Time-course effects of systemically administered diesel exhaust particles in rats

Abderrahim Nemmar, Suhail Al-Salam, Shaheen Zia, Subramanian Dhanasekaran, Munjusha Shudadevi, Badreldin H. Ali

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Nanosized fraction of particulate air pollution has been reported to translocate from the airways into the bloodstream and act on different organs. However, the direct effect of these translocated particles is not well understood. In this study, we determined the time-course (6h, 18. h, 48. h and 168. h) effects of the systemic administration of 0.02. mg/kg diesel exhaust particles (DEP) on systolic blood pressure (SBP), systemic inflammation, oxidative status, and morphological alterations in lungs, heart, liver and kidneys in Wistar rats. SBP was significantly decreased at 6. h (P

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalToxicology Letters
Volume194
Issue number3
DOIs
Publication statusPublished - May 2010

Keywords

  • Diesel exhaust particles
  • Lung inflammation
  • Rats
  • Systemic inflammation

ASJC Scopus subject areas

  • Toxicology

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