Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting

Khurram M. Siddiqui, Michelle Billia, Clarisse R. Mazzola, Ali Alzahrani, Gerald B. Brock, Christopher Scilley, Joseph L. Chin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Optimal oncologic control of higher stage prostate cancers often requires sacrificing the neurovascular bundles (NVB) with subsequent postoperative erectile dysfunction (ED), which can be treated with interposition graft using sural nerve. Aims: To examine the long term outcome of sural nerve grafting (SNG) during radical retropubic prostatectomy (RRP) performed by a single surgeon. Methods: Sixty-six patients with clinically localized prostate cancer and preoperative International Index of Erectile Function (IIEF) score >20 who underwent RRP were included. NVB excision was performed if the risk of side-specific extra-capsular extension (ECE) was >25% on Ohori' nomogram. SNG was harvested by a plastic surgeon, contemporaneously as the urologic surgeon was performing RRP. IIEF questionnaire was used pre- and postoperatively and at follow-up. Main Outcome Measures: Postoperative IIEF score at three years of men undergoing RRP with SNG. Recovery of potency was defined as postoperative IIEF-EF domain score >22. Results: There were 43 (65%) unilateral SNG and 23 (35%) bilateral SNG. Mean surgical time was 164 minutes (71 to 221 minutes).The mean preoperative IIEF score was 23.4+1.6. With a mean follow-up of 35 months, 19 (28.8%) patients had IIEF score >22. The IIEF-EF scores for those who had unilateral SNG and bilateral SNG were 12.9+4.9 and 14.8+5.3 respectively. History of diabetes (P=0.001) and age (P=0.007) negatively correlated with recovery of EF. 60% patients used PDE5i and showed a significantly higher EF recovery (43% vs. 17%, P=0.009). Conclusions: SNG can potentially improve EF recovery for potent men with higher stage prostate cancer undergoing RP. The contemporaneous, multidisciplinary approach provides a good quality graft and expedited the procedure without interrupting the work-flow. Siddiqui KM, Billia M, Mazzola CR, Alzahrani A, Brock GB, Scilley C, and Chin JL. Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting. J Sex Med 2014;11:2119-2124.

Original languageEnglish
Pages (from-to)2119-2124
Number of pages6
JournalJournal of Sexual Medicine
Volume11
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Sural Nerve
Recovery of Function
Prostatectomy
Prostatic Neoplasms
Transplants
Chin
Nomograms
Workflow
Erectile Dysfunction
Operative Time
Outcome Assessment (Health Care)

Keywords

  • Erectile function recovery
  • Errectile dysfunction
  • Prostate cancer
  • Radical prostatectomy
  • Sural nerve grafting

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Urology

Cite this

Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting. / Siddiqui, Khurram M.; Billia, Michelle; Mazzola, Clarisse R.; Alzahrani, Ali; Brock, Gerald B.; Scilley, Christopher; Chin, Joseph L.

In: Journal of Sexual Medicine, Vol. 11, No. 8, 2014, p. 2119-2124.

Research output: Contribution to journalArticle

Siddiqui, Khurram M. ; Billia, Michelle ; Mazzola, Clarisse R. ; Alzahrani, Ali ; Brock, Gerald B. ; Scilley, Christopher ; Chin, Joseph L. / Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting. In: Journal of Sexual Medicine. 2014 ; Vol. 11, No. 8. pp. 2119-2124.
@article{712ecc7eab7742eb917e671813662caf,
title = "Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting",
abstract = "Introduction: Optimal oncologic control of higher stage prostate cancers often requires sacrificing the neurovascular bundles (NVB) with subsequent postoperative erectile dysfunction (ED), which can be treated with interposition graft using sural nerve. Aims: To examine the long term outcome of sural nerve grafting (SNG) during radical retropubic prostatectomy (RRP) performed by a single surgeon. Methods: Sixty-six patients with clinically localized prostate cancer and preoperative International Index of Erectile Function (IIEF) score >20 who underwent RRP were included. NVB excision was performed if the risk of side-specific extra-capsular extension (ECE) was >25{\%} on Ohori' nomogram. SNG was harvested by a plastic surgeon, contemporaneously as the urologic surgeon was performing RRP. IIEF questionnaire was used pre- and postoperatively and at follow-up. Main Outcome Measures: Postoperative IIEF score at three years of men undergoing RRP with SNG. Recovery of potency was defined as postoperative IIEF-EF domain score >22. Results: There were 43 (65{\%}) unilateral SNG and 23 (35{\%}) bilateral SNG. Mean surgical time was 164 minutes (71 to 221 minutes).The mean preoperative IIEF score was 23.4+1.6. With a mean follow-up of 35 months, 19 (28.8{\%}) patients had IIEF score >22. The IIEF-EF scores for those who had unilateral SNG and bilateral SNG were 12.9+4.9 and 14.8+5.3 respectively. History of diabetes (P=0.001) and age (P=0.007) negatively correlated with recovery of EF. 60{\%} patients used PDE5i and showed a significantly higher EF recovery (43{\%} vs. 17{\%}, P=0.009). Conclusions: SNG can potentially improve EF recovery for potent men with higher stage prostate cancer undergoing RP. The contemporaneous, multidisciplinary approach provides a good quality graft and expedited the procedure without interrupting the work-flow. Siddiqui KM, Billia M, Mazzola CR, Alzahrani A, Brock GB, Scilley C, and Chin JL. Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting. J Sex Med 2014;11:2119-2124.",
keywords = "Erectile function recovery, Errectile dysfunction, Prostate cancer, Radical prostatectomy, Sural nerve grafting",
author = "Siddiqui, {Khurram M.} and Michelle Billia and Mazzola, {Clarisse R.} and Ali Alzahrani and Brock, {Gerald B.} and Christopher Scilley and Chin, {Joseph L.}",
year = "2014",
doi = "10.1111/jsm.12600",
language = "English",
volume = "11",
pages = "2119--2124",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting

AU - Siddiqui, Khurram M.

AU - Billia, Michelle

AU - Mazzola, Clarisse R.

AU - Alzahrani, Ali

AU - Brock, Gerald B.

AU - Scilley, Christopher

AU - Chin, Joseph L.

PY - 2014

Y1 - 2014

N2 - Introduction: Optimal oncologic control of higher stage prostate cancers often requires sacrificing the neurovascular bundles (NVB) with subsequent postoperative erectile dysfunction (ED), which can be treated with interposition graft using sural nerve. Aims: To examine the long term outcome of sural nerve grafting (SNG) during radical retropubic prostatectomy (RRP) performed by a single surgeon. Methods: Sixty-six patients with clinically localized prostate cancer and preoperative International Index of Erectile Function (IIEF) score >20 who underwent RRP were included. NVB excision was performed if the risk of side-specific extra-capsular extension (ECE) was >25% on Ohori' nomogram. SNG was harvested by a plastic surgeon, contemporaneously as the urologic surgeon was performing RRP. IIEF questionnaire was used pre- and postoperatively and at follow-up. Main Outcome Measures: Postoperative IIEF score at three years of men undergoing RRP with SNG. Recovery of potency was defined as postoperative IIEF-EF domain score >22. Results: There were 43 (65%) unilateral SNG and 23 (35%) bilateral SNG. Mean surgical time was 164 minutes (71 to 221 minutes).The mean preoperative IIEF score was 23.4+1.6. With a mean follow-up of 35 months, 19 (28.8%) patients had IIEF score >22. The IIEF-EF scores for those who had unilateral SNG and bilateral SNG were 12.9+4.9 and 14.8+5.3 respectively. History of diabetes (P=0.001) and age (P=0.007) negatively correlated with recovery of EF. 60% patients used PDE5i and showed a significantly higher EF recovery (43% vs. 17%, P=0.009). Conclusions: SNG can potentially improve EF recovery for potent men with higher stage prostate cancer undergoing RP. The contemporaneous, multidisciplinary approach provides a good quality graft and expedited the procedure without interrupting the work-flow. Siddiqui KM, Billia M, Mazzola CR, Alzahrani A, Brock GB, Scilley C, and Chin JL. Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting. J Sex Med 2014;11:2119-2124.

AB - Introduction: Optimal oncologic control of higher stage prostate cancers often requires sacrificing the neurovascular bundles (NVB) with subsequent postoperative erectile dysfunction (ED), which can be treated with interposition graft using sural nerve. Aims: To examine the long term outcome of sural nerve grafting (SNG) during radical retropubic prostatectomy (RRP) performed by a single surgeon. Methods: Sixty-six patients with clinically localized prostate cancer and preoperative International Index of Erectile Function (IIEF) score >20 who underwent RRP were included. NVB excision was performed if the risk of side-specific extra-capsular extension (ECE) was >25% on Ohori' nomogram. SNG was harvested by a plastic surgeon, contemporaneously as the urologic surgeon was performing RRP. IIEF questionnaire was used pre- and postoperatively and at follow-up. Main Outcome Measures: Postoperative IIEF score at three years of men undergoing RRP with SNG. Recovery of potency was defined as postoperative IIEF-EF domain score >22. Results: There were 43 (65%) unilateral SNG and 23 (35%) bilateral SNG. Mean surgical time was 164 minutes (71 to 221 minutes).The mean preoperative IIEF score was 23.4+1.6. With a mean follow-up of 35 months, 19 (28.8%) patients had IIEF score >22. The IIEF-EF scores for those who had unilateral SNG and bilateral SNG were 12.9+4.9 and 14.8+5.3 respectively. History of diabetes (P=0.001) and age (P=0.007) negatively correlated with recovery of EF. 60% patients used PDE5i and showed a significantly higher EF recovery (43% vs. 17%, P=0.009). Conclusions: SNG can potentially improve EF recovery for potent men with higher stage prostate cancer undergoing RP. The contemporaneous, multidisciplinary approach provides a good quality graft and expedited the procedure without interrupting the work-flow. Siddiqui KM, Billia M, Mazzola CR, Alzahrani A, Brock GB, Scilley C, and Chin JL. Three-year outcomes of recovery of erectile function after open radical prostatectomy with sural nerve grafting. J Sex Med 2014;11:2119-2124.

KW - Erectile function recovery

KW - Errectile dysfunction

KW - Prostate cancer

KW - Radical prostatectomy

KW - Sural nerve grafting

UR - http://www.scopus.com/inward/record.url?scp=84904957732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904957732&partnerID=8YFLogxK

U2 - 10.1111/jsm.12600

DO - 10.1111/jsm.12600

M3 - Article

VL - 11

SP - 2119

EP - 2124

JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

IS - 8

ER -