Thiamin status in furosemide-treated rats

Badreldin H. Ali, Ali A. Al-Qarawi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg-1 day-1 for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a deficient haemolysate due to the addition of TPP before incubation) were measured. The results indicated that, at doses of 20 and 30 mg kg-1 (but not 10 mg kg-1), furosemide produced significant effects on these indices suggestive of thiamin deficiency. In another experiment, the effect of thiamin treatment (20 and 100 μg kg-1) in rats concomitantly given furosemide (30 mg kg-1) was investigated. The high dose of the vitamin was sufficient to overcome the biochemical signs of thiamin deficiency induced by furosemide. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalPharmacological Research
Volume42
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Thiamine
Furosemide
Transketolase
Thiamine Deficiency
Thiamine Pyrophosphate
Vitamins
Erythrocytes
Urine
Liver

Keywords

  • Furosemide
  • Rats
  • Thiamin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Thiamin status in furosemide-treated rats. / Ali, Badreldin H.; Al-Qarawi, Ali A.

In: Pharmacological Research, Vol. 42, No. 1, 2000, p. 21-24.

Research output: Contribution to journalArticle

Ali, Badreldin H. ; Al-Qarawi, Ali A. / Thiamin status in furosemide-treated rats. In: Pharmacological Research. 2000 ; Vol. 42, No. 1. pp. 21-24.
@article{e8454c9e0f704b0c8bf1b618582bab37,
title = "Thiamin status in furosemide-treated rats",
abstract = "Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg-1 day-1 for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a deficient haemolysate due to the addition of TPP before incubation) were measured. The results indicated that, at doses of 20 and 30 mg kg-1 (but not 10 mg kg-1), furosemide produced significant effects on these indices suggestive of thiamin deficiency. In another experiment, the effect of thiamin treatment (20 and 100 μg kg-1) in rats concomitantly given furosemide (30 mg kg-1) was investigated. The high dose of the vitamin was sufficient to overcome the biochemical signs of thiamin deficiency induced by furosemide. (C) 2000 Academic Press.",
keywords = "Furosemide, Rats, Thiamin",
author = "Ali, {Badreldin H.} and Al-Qarawi, {Ali A.}",
year = "2000",
doi = "10.1006/phrs.1999.0632",
language = "English",
volume = "42",
pages = "21--24",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Thiamin status in furosemide-treated rats

AU - Ali, Badreldin H.

AU - Al-Qarawi, Ali A.

PY - 2000

Y1 - 2000

N2 - Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg-1 day-1 for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a deficient haemolysate due to the addition of TPP before incubation) were measured. The results indicated that, at doses of 20 and 30 mg kg-1 (but not 10 mg kg-1), furosemide produced significant effects on these indices suggestive of thiamin deficiency. In another experiment, the effect of thiamin treatment (20 and 100 μg kg-1) in rats concomitantly given furosemide (30 mg kg-1) was investigated. The high dose of the vitamin was sufficient to overcome the biochemical signs of thiamin deficiency induced by furosemide. (C) 2000 Academic Press.

AB - Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg-1 day-1 for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a deficient haemolysate due to the addition of TPP before incubation) were measured. The results indicated that, at doses of 20 and 30 mg kg-1 (but not 10 mg kg-1), furosemide produced significant effects on these indices suggestive of thiamin deficiency. In another experiment, the effect of thiamin treatment (20 and 100 μg kg-1) in rats concomitantly given furosemide (30 mg kg-1) was investigated. The high dose of the vitamin was sufficient to overcome the biochemical signs of thiamin deficiency induced by furosemide. (C) 2000 Academic Press.

KW - Furosemide

KW - Rats

KW - Thiamin

UR - http://www.scopus.com/inward/record.url?scp=0033848881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033848881&partnerID=8YFLogxK

U2 - 10.1006/phrs.1999.0632

DO - 10.1006/phrs.1999.0632

M3 - Article

C2 - 10860630

AN - SCOPUS:0033848881

VL - 42

SP - 21

EP - 24

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 1

ER -