Theileria lestoquardi in Sudan is highly diverse and genetically distinct from that in Oman

Hoyam Awad, Salama Al-Hamidhi, Abdel Rahim M. El Hussein, Younis Mohammed zein Yousif, Khalid M. Taha, Dia A. Salih, William Weir, Hamza A. Babiker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Malignant ovine theileriosis is a severe tick-borne protozoan disease of sheep and other small ruminants which is widespread in sub-Saharan Africa and the Middle East. The disease is of considerable economic importance in Sudan as the export of livestock provides a major contribution to the gross domestic product of this country. Molecular surveys have demonstrated a high prevalence of sub-clinical infections of Theileria lestoquardi, the causative agent, among small ruminants. No information is currently available on the extent of genetic diversity and genetic exchange among parasites in different areas of the country. The present study used a panel of T. lestoquardi specific micro- and mini-satellite genetic markers to assess diversity of parasites in Sudan (Africa) and compared it to that of the parasite population in Oman (Asia). A moderate level of genetic diversity was observed among parasites in Sudan, similar to that previously documented among parasites in Oman. However, a higher level of mixed-genotype infection was identified in Sudanese animals compared to Omani animals, consistent with a higher rate of tick transmission. In addition, the T. lestoquardi genotypes detected in these two countries form genetically distinct groups. The results of this work highlight the need for analysis of T. lestoquardi populations in other endemic areas in the region to inform on novel approaches for controlling malignant theileriosis.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalInfection, Genetics and Evolution
Volume62
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Theileria
Oman
Sudan
parasite
Parasites
parasites
Theileriasis
theileriosis
tick
ruminant
Ruminants
small ruminants
ticks
Sheep
genotype
Genotype
Tick-Borne Diseases
Gross Domestic Product
gross domestic product
sheep diseases

Keywords

  • Oman
  • Population genetics
  • Sudan
  • Theileria lestoquardi

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Theileria lestoquardi in Sudan is highly diverse and genetically distinct from that in Oman. / Awad, Hoyam; Al-Hamidhi, Salama; El Hussein, Abdel Rahim M.; Yousif, Younis Mohammed zein; Taha, Khalid M.; Salih, Dia A.; Weir, William; Babiker, Hamza A.

In: Infection, Genetics and Evolution, Vol. 62, 01.08.2018, p. 46-52.

Research output: Contribution to journalArticle

Awad, Hoyam ; Al-Hamidhi, Salama ; El Hussein, Abdel Rahim M. ; Yousif, Younis Mohammed zein ; Taha, Khalid M. ; Salih, Dia A. ; Weir, William ; Babiker, Hamza A. / Theileria lestoquardi in Sudan is highly diverse and genetically distinct from that in Oman. In: Infection, Genetics and Evolution. 2018 ; Vol. 62. pp. 46-52.
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