The variable neighborhood search metaheuristic for fuzzy clusering cDNA microarray gene expression data

Nabil Belacel, Miroslava Cuperlovic-Culf, Rodney Ouellette, Mohamed R. Boulassel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Several thousand genes can be monitored simultaneously using cDNA microarray technology. To exploit the huge amount of information contained in gene expression data, adaptation of existing and development of new computational methods are required. Recently, the Fuzzy C-Means (F-CM) method has been applied to cluster cDNA microarray data sets. To overcome some shortcomings of F-CM and to improve its performance, it was embedded into a variable neighborhood search (VNS) metaheuristic. The methodology was used to cluster four cDNA microarray data sets. Results show that VNS+F-CM substantially improves the findings obtained by F-CM. This methodology may yield significant benefit in the improvement of decision support systems used for gene expression classification.

Original languageEnglish
Title of host publicationProceedings of the IASTED International Conference on Artificial Intelligence and Applications (as part of the 22nd IASTED International Multi-Conference on Applied Informatics)
EditorsM.H. Hamza
Pages51-56
Number of pages6
Publication statusPublished - 2004
EventProceedings of the IASTED International Conference on Artificial Intelligence and Applications (as part of the 22nd IASTED International Multi-Conference on Applied Informatics - Innsbruck, Austria
Duration: Feb 16 2004Feb 18 2004

Other

OtherProceedings of the IASTED International Conference on Artificial Intelligence and Applications (as part of the 22nd IASTED International Multi-Conference on Applied Informatics
CountryAustria
CityInnsbruck
Period2/16/042/18/04

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Keywords

  • Bioinformatics
  • Fuzzy clustering
  • Gene expression
  • Variable neighborhood search metaheuristic

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Belacel, N., Cuperlovic-Culf, M., Ouellette, R., & Boulassel, M. R. (2004). The variable neighborhood search metaheuristic for fuzzy clusering cDNA microarray gene expression data. In M. H. Hamza (Ed.), Proceedings of the IASTED International Conference on Artificial Intelligence and Applications (as part of the 22nd IASTED International Multi-Conference on Applied Informatics) (pp. 51-56). [411-057]