TY - JOUR
T1 - The therapeutic potential of skin mucus from Asian swamp eel (Monopterus albus)
T2 - In vivo evaluation and histological evidence
AU - Hilles, Ayah Rebhi
AU - Mahmood, Syed
AU - Waly, Mostafa I.
AU - Kaderi, Mohd Arifin
AU - Ahmed, Qamar Uddin
AU - Azmi, Syed Najmul Hejaz
AU - AlAsmari, Abdullah F.
AU - Ali, Nemat
AU - Alharbi, Metab
AU - Rauf, Mohd Ahmar
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Objectives: The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods: The eel mucus was collected fleshly and topical gel with carbopol 934 was formulated to study the antibacterial activity on the infected skin of the rats. Sprague Dawley rats were used in the study and divided into 4 groups negative, positive, normal control, and treated groups. Results: Intracutaneous injections of pathogenic bacteria (Streptococcus pyogenes, Staphylococcus aureus) and fungi (Microsporum gypseum, Candida albicans) were injected into the rats. The development of tinea capitis, impetigo, and cutaneous candidiasis in the animal model was confirmed based on clinical and histopathological observations. To treat the infected rats, a formulated gel of eel skin mucus was applied on the infected rat's skins topically. The histological analysis confirms a complete recovery in the skin tissues similar to commercial antifungal and antibacterial agents used in the positive control groups. Conclusion: The present novel eel skin mucus is an efficient therapeutic candidate in treating skin infections associated with pathogenic microbes.
AB - Objectives: The Asian swamp eel (Monopterus albus), is commonly distributed in Asian countries. However, its therapeutic potential has not been thoroughly investigated yet. The current study aimed to evaluate the in-vivo therapeutic properties of the skin mucus of this fish. Methods: The eel mucus was collected fleshly and topical gel with carbopol 934 was formulated to study the antibacterial activity on the infected skin of the rats. Sprague Dawley rats were used in the study and divided into 4 groups negative, positive, normal control, and treated groups. Results: Intracutaneous injections of pathogenic bacteria (Streptococcus pyogenes, Staphylococcus aureus) and fungi (Microsporum gypseum, Candida albicans) were injected into the rats. The development of tinea capitis, impetigo, and cutaneous candidiasis in the animal model was confirmed based on clinical and histopathological observations. To treat the infected rats, a formulated gel of eel skin mucus was applied on the infected rat's skins topically. The histological analysis confirms a complete recovery in the skin tissues similar to commercial antifungal and antibacterial agents used in the positive control groups. Conclusion: The present novel eel skin mucus is an efficient therapeutic candidate in treating skin infections associated with pathogenic microbes.
KW - Eel skin mucus
KW - Intracutaneous injections
KW - Monopterus albus
KW - Skin infections
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U2 - 10.1016/j.jksus.2022.102011
DO - 10.1016/j.jksus.2022.102011
M3 - Article
AN - SCOPUS:85128238830
SN - 1018-3647
VL - 34
JO - Journal of King Saud University - Science
JF - Journal of King Saud University - Science
IS - 4
M1 - 102011
ER -