TY - JOUR
T1 - The spectrum of bleeding disorders in women with menorrhagia
T2 - A report from Western India
AU - Trasi, Sucheta A.
AU - Pathare, Anil V.
AU - Shetty, Shrimati D.
AU - Ghosh, Kanjaksha
AU - Salvi, Vinita
AU - Mohanty, Dipika
N1 - Funding Information:
Acknowledgments We would like to thank the Lady Tata Memorial trust, Mumbai for partly funding the project.
PY - 2005/5
Y1 - 2005/5
N2 - In order to evaluate the incidence of hereditary bleeding disorders in patients presenting with menorrhagia, where the usual gynecological and endocrinal causes of bleeding were ruled out by various local ultrasonography (USG) and relevant endocrine investigations, 120 women aged between 18 and 35 years presenting with menorrhagia without any discernable cause were studied using an open design, where the investigators knew that these patients had menorrhagia. These patients were investigated for inherited coagulation defects. Of the 120 women investigated, 19.16% (23 cases) had an inherited coagulation disorder to account for their menorrhagia. Although a majority (11.6%) are patients with von Willebrand's disease (VWD), other rare platelet disorders such as Glanzmann's thrombasthenia (3.3%), Bernard-Soulier syndrome (0.83%), coagulation factor deficiencies such as factor VIII (0.83%), factor X (0.83%), and factor XI (0.83%), and immune thrombocytopenia (0.83%) were also found. Taking a detailed history for bleeding from other sites howsoever minor, paternal consanguinity as well as family history of bleeding tendencies appeared as a very strong predictor for such kinds of disease in patients with menorrhagia. Patients with menorrhagia without a discernable cause, therefore, need evaluation for the congenital coagulation disorders.
AB - In order to evaluate the incidence of hereditary bleeding disorders in patients presenting with menorrhagia, where the usual gynecological and endocrinal causes of bleeding were ruled out by various local ultrasonography (USG) and relevant endocrine investigations, 120 women aged between 18 and 35 years presenting with menorrhagia without any discernable cause were studied using an open design, where the investigators knew that these patients had menorrhagia. These patients were investigated for inherited coagulation defects. Of the 120 women investigated, 19.16% (23 cases) had an inherited coagulation disorder to account for their menorrhagia. Although a majority (11.6%) are patients with von Willebrand's disease (VWD), other rare platelet disorders such as Glanzmann's thrombasthenia (3.3%), Bernard-Soulier syndrome (0.83%), coagulation factor deficiencies such as factor VIII (0.83%), factor X (0.83%), and factor XI (0.83%), and immune thrombocytopenia (0.83%) were also found. Taking a detailed history for bleeding from other sites howsoever minor, paternal consanguinity as well as family history of bleeding tendencies appeared as a very strong predictor for such kinds of disease in patients with menorrhagia. Patients with menorrhagia without a discernable cause, therefore, need evaluation for the congenital coagulation disorders.
KW - Bleeding disorders
KW - India
KW - Menorrhagia
KW - Von Willebrand's disease
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U2 - 10.1007/s00277-004-0905-4
DO - 10.1007/s00277-004-0905-4
M3 - Article
C2 - 15290102
AN - SCOPUS:22944462181
SN - 0939-5555
VL - 84
SP - 339
EP - 342
JO - Annals of Hematology
JF - Annals of Hematology
IS - 5
ER -