The spectrum of bleeding disorders in women with menorrhagia: A report from Western India

Sucheta A. Trasi, Anil V. Pathare, Shrimati D. Shetty, Kanjaksha Ghosh, Vinita Salvi, Dipika Mohanty

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In order to evaluate the incidence of hereditary bleeding disorders in patients presenting with menorrhagia, where the usual gynecological and endocrinal causes of bleeding were ruled out by various local ultrasonography (USG) and relevant endocrine investigations, 120 women aged between 18 and 35 years presenting with menorrhagia without any discernable cause were studied using an open design, where the investigators knew that these patients had menorrhagia. These patients were investigated for inherited coagulation defects. Of the 120 women investigated, 19.16% (23 cases) had an inherited coagulation disorder to account for their menorrhagia. Although a majority (11.6%) are patients with von Willebrand's disease (VWD), other rare platelet disorders such as Glanzmann's thrombasthenia (3.3%), Bernard-Soulier syndrome (0.83%), coagulation factor deficiencies such as factor VIII (0.83%), factor X (0.83%), and factor XI (0.83%), and immune thrombocytopenia (0.83%) were also found. Taking a detailed history for bleeding from other sites howsoever minor, paternal consanguinity as well as family history of bleeding tendencies appeared as a very strong predictor for such kinds of disease in patients with menorrhagia. Patients with menorrhagia without a discernable cause, therefore, need evaluation for the congenital coagulation disorders.

Original languageEnglish
Pages (from-to)339-342
Number of pages4
JournalAnnals of Hematology
Volume84
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Menorrhagia
India
Hemorrhage
Inherited Blood Coagulation Disorders
Bernard-Soulier Syndrome
Thrombasthenia
Factor XI
Consanguinity
von Willebrand Diseases
Factor X
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Blood Coagulation Factors
Idiopathic Thrombocytopenic Purpura
Factor VIII
Ultrasonography
Blood Platelets
History
Research Personnel
Incidence

Keywords

  • Bleeding disorders
  • India
  • Menorrhagia
  • Von Willebrand's disease

ASJC Scopus subject areas

  • Hematology

Cite this

The spectrum of bleeding disorders in women with menorrhagia : A report from Western India. / Trasi, Sucheta A.; Pathare, Anil V.; Shetty, Shrimati D.; Ghosh, Kanjaksha; Salvi, Vinita; Mohanty, Dipika.

In: Annals of Hematology, Vol. 84, No. 5, 05.2005, p. 339-342.

Research output: Contribution to journalArticle

Trasi, Sucheta A. ; Pathare, Anil V. ; Shetty, Shrimati D. ; Ghosh, Kanjaksha ; Salvi, Vinita ; Mohanty, Dipika. / The spectrum of bleeding disorders in women with menorrhagia : A report from Western India. In: Annals of Hematology. 2005 ; Vol. 84, No. 5. pp. 339-342.
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