The spectrum of bacterial infections in febrile neutropenic patients

Effect on empiric antibiotic therapy

Ikram A. Burney, Badar J. Farooqui, Tariq Siddiqui, Mohammed Khurshid

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The aim of this retrospective analysis was to look at the spectrum of bacterial isolates and their resistance patterns to the commonly used antibiotics in the setting of febrile neutropenia. A total of 127 bacteria were isolated from patients with acute leukemias, lymphoproliferative disorders, a plastic anaemia and various solid tumours. Fifty-four percent organisms were gram negative; while the rest were gram positive. E. coli, pseudomonas aeruginosa, staphylococcus aureus, enterococcus and streptococci were the commonly isolated organisms. Forty-eight percent organisms were isolated from blood, 16% from urine, 13% from wounds and superficial abscesses and 11% from respiratory tract. E. coli exhibited a great degree of resistance to the commonly used antibiotics, such as pipericillin (70%), ofloxacin (50%) and aztreonam (50%). Pseudomonas and klebsiella also showed varying degree of resistance against the antibiotics. Staphylococcus aureus and staphylococcus epidermidis were almost universally resistant to penicillin and showed a variable degree of resistance to other antibiotics too. Compared to the previous reports, the pattern of bacterial isolates and their resistance to antibiotics has changed over the past years. Aminoglycosides and third generation cephalosporins seem to be the choice of antibiotics for the upfront management of febrile neutropenic patients.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalJournal of the Pakistan Medical Association
Volume48
Issue number12
Publication statusPublished - 1998

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Bacterial Infections
Fever
Anti-Bacterial Agents
Microbial Drug Resistance
Staphylococcus aureus
Escherichia coli
Aztreonam
Febrile Neutropenia
Ofloxacin
Klebsiella
Staphylococcus epidermidis
Lymphoproliferative Disorders
Enterococcus
Aminoglycosides
Cephalosporins
Therapeutics
Pseudomonas
Streptococcus
Penicillins
Respiratory System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The spectrum of bacterial infections in febrile neutropenic patients : Effect on empiric antibiotic therapy. / Burney, Ikram A.; Farooqui, Badar J.; Siddiqui, Tariq; Khurshid, Mohammed.

In: Journal of the Pakistan Medical Association, Vol. 48, No. 12, 1998, p. 364-367.

Research output: Contribution to journalArticle

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