The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Chiranjib Chakraborty, Teoh Seong Lin, Srijit Das*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.

Original languageEnglish
JournalCurrent Drug Targets
Volume17
Issue number16
DOIs
Publication statusPublished - May 20 2016
Externally publishedYes

Keywords

  • Applications
  • Cas9
  • CRISPR
  • Genome editing
  • Medicine
  • Technology

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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