The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.
|Journal||Current Drug Targets|
|Publication status||Published - May 20 2016|
- Genome editing
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Clinical Biochemistry