The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Chiranjib Chakraborty; Teoh Seong Lin; Srijit Das

doi:10.2174/1389450117666160527142321

The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Chiranjib Chakraborty, Teoh Seong Lin, Srijit Das^*

^*Corresponding author for this work

Human & Clinical Anatomy

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.

Original language	English
Journal	Current Drug Targets
Volume	17
Issue number	16
DOIs	https://doi.org/10.2174/1389450117666160527142321
Publication status	Published - May 20 2016

Keywords

Applications
CRISPR
Cas9
Genome editing
Medicine
Technology

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

Access to Document

10.2174/1389450117666160527142321

Cite this

@article{beac040f463d4ac593928a2aecf0c16e,

title = "The smart programmable CRISPR technology: A next generation genome editing tool for investigators",

abstract = "The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.",

keywords = "Applications, CRISPR, Cas9, Genome editing, Medicine, Technology",

author = "Chiranjib Chakraborty and Lin, {Teoh Seong} and Srijit Das",

note = "Publisher Copyright: {\textcopyright} 2016 Bentham Science Publishers.",

year = "2016",

month = may,

day = "20",

doi = "10.2174/1389450117666160527142321",

language = "English",

volume = "17",

journal = "Current Drug Targets",

issn = "1389-4501",

publisher = "Bentham Science Publishers B.V.",

number = "16",

}

TY - JOUR

T1 - The smart programmable CRISPR technology

T2 - A next generation genome editing tool for investigators

AU - Chakraborty, Chiranjib

AU - Lin, Teoh Seong

AU - Das, Srijit

PY - 2016/5/20

Y1 - 2016/5/20

N2 - The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.

AB - The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.

KW - Applications

KW - CRISPR

KW - Cas9

KW - Genome editing

KW - Medicine

KW - Technology

UR - http://www.scopus.com/inward/record.url?scp=85010703077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010703077&partnerID=8YFLogxK

U2 - 10.2174/1389450117666160527142321

DO - 10.2174/1389450117666160527142321

M3 - Review article

C2 - 27231109

AN - SCOPUS:85010703077

SN - 1389-4501

VL - 17

JO - Current Drug Targets

JF - Current Drug Targets

IS - 16

ER -

The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this