The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Chiranjib Chakraborty; Teoh Seong Lin; Srijit Das

doi:10.2174/1389450117666160527142321

The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Chiranjib Chakraborty, Teoh Seong Lin, Srijit Das^*

^*Corresponding author for this work

Human & Clinical Anatomy

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.

Original language	English
Journal	Current Drug Targets
Volume	17
Issue number	16
DOIs	https://doi.org/10.2174/1389450117666160527142321
Publication status	Published - May 20 2016

Keywords

Applications
Cas9
CRISPR
Genome editing
Medicine
Technology

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.2174/1389450117666160527142321

Cite this

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abstract = "The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.",

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AB - The present era is fast experiencing rapid innovation in the genome-editing technology: CRISPR Cas9-mediated targeted genetic manipulation is an easy, cost-effective and scalable method. As a result, it can be used for a broad range of targeted genome engineering. Hence, there is a huge opening for investigators in the area of the targeted genome engineering of different kind of genes. The genome engineering technology is a very strong and inspiring technology meant for the next generation of drug development. The present review provides a brief description of the recent development of CRISPR-Cas9 genome editing technology. We also describe the structural signature, classification, its mechanism and application from basic science to medicine and highlight the future challenges for this genome editing tool kit.

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The smart programmable CRISPR technology: A next generation genome editing tool for investigators

Abstract

Keywords

ASJC Scopus subject areas

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