The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review

Shanmugam Manoharan, Gilles J. Guillemin, Rajagopal Selladurai Abiramasundari, Musthafa Mohamed Essa, Mohammed Akbar, Mohammed D. Akbar

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer's disease (AD), impairments in the movement, Parkinson's disease (PD), and the inability to walk, talk, and think, Huntington's disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.

Original languageEnglish
Article number8590578
JournalOxidative Medicine and Cellular Longevity
Volume2016
DOIs
Publication statusPublished - 2016

Fingerprint

Huntington Disease
Neurodegenerative Diseases
Parkinson Disease
Reactive Oxygen Species
Alzheimer Disease
Neurodegenerative diseases
Oxidative Stress
Oxidative stress
Brain Diseases
Biological Products
Memory Disorders
Traditional Medicine
Medicinal Plants
Oxidants
Brain
Animal Models
Antioxidants
Biomarkers
Quality of Life
Population

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease : A Mini Review. / Manoharan, Shanmugam; Guillemin, Gilles J.; Abiramasundari, Rajagopal Selladurai; Essa, Musthafa Mohamed; Akbar, Mohammed; Akbar, Mohammed D.

In: Oxidative Medicine and Cellular Longevity, Vol. 2016, 8590578, 2016.

Research output: Contribution to journalReview article

Manoharan, Shanmugam ; Guillemin, Gilles J. ; Abiramasundari, Rajagopal Selladurai ; Essa, Musthafa Mohamed ; Akbar, Mohammed ; Akbar, Mohammed D. / The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease : A Mini Review. In: Oxidative Medicine and Cellular Longevity. 2016 ; Vol. 2016.
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