The relationship between tumor cell differentiation and age at diagnosis in retinoblastoma

Jagadeesan Madhavan*, Anuradha Ganesh, Joseph Roy, Jyotirmay Biswas, Govindasamy Kumaramanickavel

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma. Methods: Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed. Results: Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P <.0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors. Conclusions: Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalJournal of Pediatric Ophthalmology and Strabismus
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2008

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

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