TY - JOUR
T1 - The relationship between tumor cell differentiation and age at diagnosis in retinoblastoma
AU - Madhavan, Jagadeesan
AU - Ganesh, Anuradha
AU - Roy, Joseph
AU - Biswas, Jyotirmay
AU - Kumaramanickavel, Govindasamy
PY - 2008/1
Y1 - 2008/1
N2 - Purpose: To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma. Methods: Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed. Results: Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P < .0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors. Conclusions: Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.
AB - Purpose: To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma. Methods: Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed. Results: Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P < .0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors. Conclusions: Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.
UR - http://www.scopus.com/inward/record.url?scp=40849092627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40849092627&partnerID=8YFLogxK
U2 - 10.3928/01913913-20080101-16
DO - 10.3928/01913913-20080101-16
M3 - Article
C2 - 18286958
AN - SCOPUS:40849092627
SN - 0191-3913
VL - 45
SP - 22
EP - 25
JO - Journal of Pediatric Ophthalmology and Strabismus
JF - Journal of Pediatric Ophthalmology and Strabismus
IS - 1
ER -