The past, current and future trends in DNA vaccine immunisations

Sidgi Syed Anwer Abdo Hasson, Juma Khalifa Zayid Al-Busaidi, Talal Abdulmalek Sallam

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immunization by inducing potent cellular immune responses against infectious and non-infectious diseases. It is well documented that injection of DNA plasmid encoding a desired gene of interest can result in the subsequent expression of its products and lead to the induction of an immune response within a host. This is pertinent to prophylactic and therapeutic vaccination approach when the peculiar gene produces a protective epitope from a pathogen. The recent studies demonstrated by a number of research centers showed that these immune responses evoke protective immunity against several infectious diseases and cancers, which provides adequate support for the use of this approach. We attempt in this review to provide an informative and unbiased overview of the general principles and concept of DNA vaccines technology with a summary of a novel approach to the DNA vaccine, present investigations that describe the mechanism(s) of protective immunity provoked by DNA immunization and to highlight the advantages and disadvantages of DNA immunisation.

Original languageEnglish
Pages (from-to)344-353
Number of pages10
JournalAsian Pacific Journal of Tropical Biomedicine
Volume5
Issue number5
DOIs
Publication statusPublished - 2015

Fingerprint

Immunization
DNA Vaccines
Immunity
DNA
Genes
Pathogens
Cellular Immunity
Communicable Diseases
Epitopes
Vaccination
Plasmids
Technology
Injections
Research
Neoplasms

Keywords

  • Bioechnology
  • Clinical trials
  • DNA
  • Immunotherapy
  • Plasmid
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

The past, current and future trends in DNA vaccine immunisations. / Hasson, Sidgi Syed Anwer Abdo; Al-Busaidi, Juma Khalifa Zayid; Sallam, Talal Abdulmalek.

In: Asian Pacific Journal of Tropical Biomedicine, Vol. 5, No. 5, 2015, p. 344-353.

Research output: Contribution to journalArticle

Hasson, Sidgi Syed Anwer Abdo ; Al-Busaidi, Juma Khalifa Zayid ; Sallam, Talal Abdulmalek. / The past, current and future trends in DNA vaccine immunisations. In: Asian Pacific Journal of Tropical Biomedicine. 2015 ; Vol. 5, No. 5. pp. 344-353.
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