The p53 mutation/deletion profile in a small cohort of the Omani population with diffuse large B-cell Lymphoma

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Abstract

Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods: Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4-9 of the p53 gene. Results: While 35% of patients analysed displayed allelic deletions (P

Original languageEnglish
JournalSultan Qaboos University Medical Journal
Volume14
Issue number1
Publication statusPublished - Jan 2014

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Keywords

  • B-cell
  • Gene deletion
  • Immunohistochemistry
  • Lymphoma
  • Mutations
  • Oman
  • Paraffin embedding

ASJC Scopus subject areas

  • Medicine(all)

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