The p53 mutation/deletion profile in a small cohort of the Omani population with diffuse large B-cell Lymphoma

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2 Citations (Scopus)

Abstract

Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods: Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4-9 of the p53 gene. Results: While 35% of patients analysed displayed allelic deletions (P

Original languageEnglish
JournalSultan Qaboos University Medical Journal
Volume14
Issue number1
Publication statusPublished - Jan 2014

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Sequence Deletion
p53 Genes
Population
Paraffin
Exons
Polymerase Chain Reaction
DNA

Keywords

  • B-cell
  • Gene deletion
  • Immunohistochemistry
  • Lymphoma
  • Mutations
  • Oman
  • Paraffin embedding

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods: Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4-9 of the p53 gene. Results: While 35{\%} of patients analysed displayed allelic deletions (P",
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author = "Yahya Tamimi and Sheikha Al-Harthy and Ibrahim Al-Haddabi and Mohammed Al-Kindi and Hamza Babiker and Mansour Al-Moundhri and Ikram Burney",
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T1 - The p53 mutation/deletion profile in a small cohort of the Omani population with diffuse large B-cell Lymphoma

AU - Tamimi, Yahya

AU - Al-Harthy, Sheikha

AU - Al-Haddabi, Ibrahim

AU - Al-Kindi, Mohammed

AU - Babiker, Hamza

AU - Al-Moundhri, Mansour

AU - Burney, Ikram

PY - 2014/1

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N2 - Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods: Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4-9 of the p53 gene. Results: While 35% of patients analysed displayed allelic deletions (P

AB - Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods: Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4-9 of the p53 gene. Results: While 35% of patients analysed displayed allelic deletions (P

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KW - Gene deletion

KW - Immunohistochemistry

KW - Lymphoma

KW - Mutations

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KW - Paraffin embedding

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