TY - JOUR
T1 - The outcome of treatment of breast cancer in a developing country - Oman
AU - Al-Moundhri, A.
AU - Al-Bahrani, B.
AU - Pervez, I.
AU - Ganguly, S. S.
AU - Nirmala, V.
AU - Al-Madhani, A.
AU - Al-Mawalay, K.
AU - Grant, C.
PY - 2004/4
Y1 - 2004/4
N2 - The aim of the present study was to evaluate the outcome of treatment of breast cancer in Oman with an analysis of clinico-pathological features, treatment modalities utilized, and prognostic factors. One hundred fifty-two breast cancer patients diagnosed between January 1996 and June 2002 were evaluated retrospectively. Their mean age was 48.5 (S.D.±10.8) years, and 48% of the female patients were premenopausal. The mean tumor size according to pathology was 4.6 (S.D. 3.29) cm, and 34.9% and 15.8% of patients had stage III or IV disease, respectively. Only 26.3% of the patients had breast-conserving surgery, and neoadjuvant chemotherapy was underutilized. The overall 5-year relapse-free survival (RFS) and overall (OS) survival rates were 62% and 64%, respectively. On multivariate analysis, axillary lymph node involvement and tumor differentiation were predictive of RFS and OS, respectively. Thus, breast cancer patients in Oman present with advanced stages of the disease at younger ages than their counterparts in the West and have lower survival rates. Increasing awareness and the introduction of screening programs and of a multidisciplinary approach are essential in Oman and other developing countries to improve the outcome of treatment.
AB - The aim of the present study was to evaluate the outcome of treatment of breast cancer in Oman with an analysis of clinico-pathological features, treatment modalities utilized, and prognostic factors. One hundred fifty-two breast cancer patients diagnosed between January 1996 and June 2002 were evaluated retrospectively. Their mean age was 48.5 (S.D.±10.8) years, and 48% of the female patients were premenopausal. The mean tumor size according to pathology was 4.6 (S.D. 3.29) cm, and 34.9% and 15.8% of patients had stage III or IV disease, respectively. Only 26.3% of the patients had breast-conserving surgery, and neoadjuvant chemotherapy was underutilized. The overall 5-year relapse-free survival (RFS) and overall (OS) survival rates were 62% and 64%, respectively. On multivariate analysis, axillary lymph node involvement and tumor differentiation were predictive of RFS and OS, respectively. Thus, breast cancer patients in Oman present with advanced stages of the disease at younger ages than their counterparts in the West and have lower survival rates. Increasing awareness and the introduction of screening programs and of a multidisciplinary approach are essential in Oman and other developing countries to improve the outcome of treatment.
KW - Breast cancer
KW - Developing country
KW - Oman
UR - http://www.scopus.com/inward/record.url?scp=1842588684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842588684&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2003.10.001
DO - 10.1016/j.breast.2003.10.001
M3 - Article
C2 - 15019695
AN - SCOPUS:1842588684
SN - 0960-9776
VL - 13
SP - 139
EP - 145
JO - Breast
JF - Breast
IS - 2
ER -
