The need for new anti-hepatitis C virus therapeutic strategies: Targeting the cellular micro-ribonucleic acids?

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalSultan Qaboos University Medical Journal
Volume10
Issue number3
Publication statusPublished - Dec 1 2010

Fingerprint

Hepacivirus
RNA
Therapeutics
Chronic Hepatitis C
Virus Diseases
Virus Replication
Infection
Population

Keywords

  • Hepatitis C virus
  • Infection
  • Interferon
  • Liver
  • MicroRNAs
  • Therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "The need for new anti-hepatitis C virus therapeutic strategies: Targeting the cellular micro-ribonucleic acids?",
abstract = "Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.",
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N2 - Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.

AB - Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic. Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance.

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KW - Interferon

KW - Liver

KW - MicroRNAs

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