The impact of the method of consent on response rates in the ISAAC time trends study

Philippa Ellwood, M. I. Asher, A. W. Stewart, N. Aït-Khaled, H. R. Anderson, R. Beasley, B. Björkstén, B. Brunekreef, J. Crane, C. Flohr, S. Foliaki, F. Forastiere, L. García-Marcos, U. Keil, C. K W Lai, J. Mallol, E. A. Mitchell, S. Montefort, J. Odhiambo, N. PearceC. F. Robertson, D. Strachan, E. von Mutius, S. K. Weiland, G. Weinmayr, H. Williams, G. Wong, T. O. Clayton, B. Benhabylès, F. O. Esamai, L. Ng'ang'a, Z. Bouayad, B. O. Onadeko, H. J. Zar, M. Jerray, Y. Z. Chen, N. S. Zhong, Y. L. Lau, C. B. Kartasasmita, H. Odajima, K. H. Teh, J. de Bruyne, B. S. Quah, F. Cua-Lim, D. Y T Goh, H. B. Lee, J. L. Huang, P. Vichyanond, M. Trakultivakom, M. R. Masjedi, J. A. al-Momen, N. Mahmood, O. Al-Rawas, V. A. Khatav, L. Kumar, G. Setty, K. C. Jain, T. U. Sukumaran, M. K. Joshi, A. V. Pherwani, S. K. Sharma, N. M. Hanumante, I. M E Guimaraes, C. E. Baena-Cagnani, N. Rosário, G. B. Fischer, M. de Britto, L. de Freitas Souza, D. Solé, L. Amarales, P. Aguilar, M. A. Calvo, M. E. Soto-Quirós, I. Romieu, G. Cukier, J. A. Guggiari-Chase, P. Chiarella, D. Holgado, M. E. Howitt, M. Sears, D. Rennie, K. Yeatts, G. J. Redding, A. Priftanji, M. A. Riikjärv, J. Pekkanen, M. Gotua, V. Svabe, J. Kudzyte, G. Lis, A. Breborowicz, D. Deleanu, E. G. Kondiourina, H. Vogt, V. Ognev, G. Marks, C. Moyes, P. Pattemore, R. Mackay, G. Haidinger, J. Weyler, P. Standring, R. Goulding, A. Steriu, E. Bonci, C. Galassi, M. G. Petronio, E. Chellini, L. Bisanti, P. Sestini, G. Ciccone, S. Piffer, R. Camâra, J. E. Rosado Pinto, C. Nunes, J. M Lopes dos Santos, L. Clancy, R. M. Busquets, C. González Díaz, A. Arnedo-Pena, G. Garcia Hernández, F. Guillén-Grima, M. M. Morales-Suarez-Varela, A. Blanco Quirós, North Thames, J. B. Austin, M. H. Shamssain, D. Strachan, M. Burr, J. Shah, K. Baratawidjaja, S. Nishima, M. Baeza-Bacab, P. Manning, R. M. Khaitov, B. Lee, L. Nilsson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND: Centres in Phases I and III of the International Study of Asthma and Allergies in Childhood (ISAAC) programme used the method of consent (passive or active) required by local ethics committees. METHODS: Retrospectively, relationships between achieved response rates and method of consent for 13-14 and 6-7-year-olds (adolescents and children, respectively), were examined between phases and between English and non-English language centres. RESULTS: Information was obtained for 113 of 115 centres for adolescents and 72/72 centres for children. Both age groups: most centres using passive consent achieved high response rates (>80% adolescents and >70% children). English language centres using active consent showed a larger decrease in response rate. Adolescents: seven centres changed from passive consent in Phase I to active consent in Phase III (median decrease of 13%), with five centres showing lower response rates (as low as 34%). Children: no centre changed consent method between phases. Centres using active consent had lower median response rates (lowest response rate 45%). CONCLUSION: The requirement for active consent for population school-based questionnaire studies can impact negatively on response rates, particularly English language centres, thus adversely affecting the validity of the data. Ethics committees need to consider this issue carefully.

Original languageEnglish
Pages (from-to)1059-1065
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume14
Issue number8
Publication statusPublished - 2010

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Hypersensitivity
Asthma
Ethics Committees
Language
Age Groups
Population

Keywords

  • Asthma
  • Children
  • Consent
  • Epidemiology
  • ISAAC

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Ellwood, P., Asher, M. I., Stewart, A. W., Aït-Khaled, N., Anderson, H. R., Beasley, R., ... Nilsson, L. (2010). The impact of the method of consent on response rates in the ISAAC time trends study. International Journal of Tuberculosis and Lung Disease, 14(8), 1059-1065.

The impact of the method of consent on response rates in the ISAAC time trends study. / Ellwood, Philippa; Asher, M. I.; Stewart, A. W.; Aït-Khaled, N.; Anderson, H. R.; Beasley, R.; Björkstén, B.; Brunekreef, B.; Crane, J.; Flohr, C.; Foliaki, S.; Forastiere, F.; García-Marcos, L.; Keil, U.; Lai, C. K W; Mallol, J.; Mitchell, E. A.; Montefort, S.; Odhiambo, J.; Pearce, N.; Robertson, C. F.; Strachan, D.; von Mutius, E.; Weiland, S. K.; Weinmayr, G.; Williams, H.; Wong, G.; Clayton, T. O.; Benhabylès, B.; Esamai, F. O.; Ng'ang'a, L.; Bouayad, Z.; Onadeko, B. O.; Zar, H. J.; Jerray, M.; Chen, Y. Z.; Zhong, N. S.; Lau, Y. L.; Kartasasmita, C. B.; Odajima, H.; Teh, K. H.; de Bruyne, J.; Quah, B. S.; Cua-Lim, F.; Goh, D. Y T; Lee, H. B.; Huang, J. L.; Vichyanond, P.; Trakultivakom, M.; Masjedi, M. R.; al-Momen, J. A.; Mahmood, N.; Al-Rawas, O.; Khatav, V. A.; Kumar, L.; Setty, G.; Jain, K. C.; Sukumaran, T. U.; Joshi, M. K.; Pherwani, A. V.; Sharma, S. K.; Hanumante, N. M.; Guimaraes, I. M E; Baena-Cagnani, C. E.; Rosário, N.; Fischer, G. B.; de Britto, M.; de Freitas Souza, L.; Solé, D.; Amarales, L.; Aguilar, P.; Calvo, M. A.; Soto-Quirós, M. E.; Romieu, I.; Cukier, G.; Guggiari-Chase, J. A.; Chiarella, P.; Holgado, D.; Howitt, M. E.; Sears, M.; Rennie, D.; Yeatts, K.; Redding, G. J.; Priftanji, A.; Riikjärv, M. A.; Pekkanen, J.; Gotua, M.; Svabe, V.; Kudzyte, J.; Lis, G.; Breborowicz, A.; Deleanu, D.; Kondiourina, E. G.; Vogt, H.; Ognev, V.; Marks, G.; Moyes, C.; Pattemore, P.; Mackay, R.; Haidinger, G.; Weyler, J.; Standring, P.; Goulding, R.; Steriu, A.; Bonci, E.; Galassi, C.; Petronio, M. G.; Chellini, E.; Bisanti, L.; Sestini, P.; Ciccone, G.; Piffer, S.; Camâra, R.; Rosado Pinto, J. E.; Nunes, C.; dos Santos, J. M Lopes; Clancy, L.; Busquets, R. M.; González Díaz, C.; Arnedo-Pena, A.; Garcia Hernández, G.; Guillén-Grima, F.; Morales-Suarez-Varela, M. M.; Blanco Quirós, A.; Thames, North; Austin, J. B.; Shamssain, M. H.; Strachan, D.; Burr, M.; Shah, J.; Baratawidjaja, K.; Nishima, S.; Baeza-Bacab, M.; Manning, P.; Khaitov, R. M.; Lee, B.; Nilsson, L.

In: International Journal of Tuberculosis and Lung Disease, Vol. 14, No. 8, 2010, p. 1059-1065.

Research output: Contribution to journalArticle

Ellwood, P, Asher, MI, Stewart, AW, Aït-Khaled, N, Anderson, HR, Beasley, R, Björkstén, B, Brunekreef, B, Crane, J, Flohr, C, Foliaki, S, Forastiere, F, García-Marcos, L, Keil, U, Lai, CKW, Mallol, J, Mitchell, EA, Montefort, S, Odhiambo, J, Pearce, N, Robertson, CF, Strachan, D, von Mutius, E, Weiland, SK, Weinmayr, G, Williams, H, Wong, G, Clayton, TO, Benhabylès, B, Esamai, FO, Ng'ang'a, L, Bouayad, Z, Onadeko, BO, Zar, HJ, Jerray, M, Chen, YZ, Zhong, NS, Lau, YL, Kartasasmita, CB, Odajima, H, Teh, KH, de Bruyne, J, Quah, BS, Cua-Lim, F, Goh, DYT, Lee, HB, Huang, JL, Vichyanond, P, Trakultivakom, M, Masjedi, MR, al-Momen, JA, Mahmood, N, Al-Rawas, O, Khatav, VA, Kumar, L, Setty, G, Jain, KC, Sukumaran, TU, Joshi, MK, Pherwani, AV, Sharma, SK, Hanumante, NM, Guimaraes, IME, Baena-Cagnani, CE, Rosário, N, Fischer, GB, de Britto, M, de Freitas Souza, L, Solé, D, Amarales, L, Aguilar, P, Calvo, MA, Soto-Quirós, ME, Romieu, I, Cukier, G, Guggiari-Chase, JA, Chiarella, P, Holgado, D, Howitt, ME, Sears, M, Rennie, D, Yeatts, K, Redding, GJ, Priftanji, A, Riikjärv, MA, Pekkanen, J, Gotua, M, Svabe, V, Kudzyte, J, Lis, G, Breborowicz, A, Deleanu, D, Kondiourina, EG, Vogt, H, Ognev, V, Marks, G, Moyes, C, Pattemore, P, Mackay, R, Haidinger, G, Weyler, J, Standring, P, Goulding, R, Steriu, A, Bonci, E, Galassi, C, Petronio, MG, Chellini, E, Bisanti, L, Sestini, P, Ciccone, G, Piffer, S, Camâra, R, Rosado Pinto, JE, Nunes, C, dos Santos, JML, Clancy, L, Busquets, RM, González Díaz, C, Arnedo-Pena, A, Garcia Hernández, G, Guillén-Grima, F, Morales-Suarez-Varela, MM, Blanco Quirós, A, Thames, N, Austin, JB, Shamssain, MH, Strachan, D, Burr, M, Shah, J, Baratawidjaja, K, Nishima, S, Baeza-Bacab, M, Manning, P, Khaitov, RM, Lee, B & Nilsson, L 2010, 'The impact of the method of consent on response rates in the ISAAC time trends study', International Journal of Tuberculosis and Lung Disease, vol. 14, no. 8, pp. 1059-1065.
Ellwood P, Asher MI, Stewart AW, Aït-Khaled N, Anderson HR, Beasley R et al. The impact of the method of consent on response rates in the ISAAC time trends study. International Journal of Tuberculosis and Lung Disease. 2010;14(8):1059-1065.
Ellwood, Philippa ; Asher, M. I. ; Stewart, A. W. ; Aït-Khaled, N. ; Anderson, H. R. ; Beasley, R. ; Björkstén, B. ; Brunekreef, B. ; Crane, J. ; Flohr, C. ; Foliaki, S. ; Forastiere, F. ; García-Marcos, L. ; Keil, U. ; Lai, C. K W ; Mallol, J. ; Mitchell, E. A. ; Montefort, S. ; Odhiambo, J. ; Pearce, N. ; Robertson, C. F. ; Strachan, D. ; von Mutius, E. ; Weiland, S. K. ; Weinmayr, G. ; Williams, H. ; Wong, G. ; Clayton, T. O. ; Benhabylès, B. ; Esamai, F. O. ; Ng'ang'a, L. ; Bouayad, Z. ; Onadeko, B. O. ; Zar, H. J. ; Jerray, M. ; Chen, Y. Z. ; Zhong, N. S. ; Lau, Y. L. ; Kartasasmita, C. B. ; Odajima, H. ; Teh, K. H. ; de Bruyne, J. ; Quah, B. S. ; Cua-Lim, F. ; Goh, D. Y T ; Lee, H. B. ; Huang, J. L. ; Vichyanond, P. ; Trakultivakom, M. ; Masjedi, M. R. ; al-Momen, J. A. ; Mahmood, N. ; Al-Rawas, O. ; Khatav, V. A. ; Kumar, L. ; Setty, G. ; Jain, K. C. ; Sukumaran, T. U. ; Joshi, M. K. ; Pherwani, A. V. ; Sharma, S. K. ; Hanumante, N. M. ; Guimaraes, I. M E ; Baena-Cagnani, C. E. ; Rosário, N. ; Fischer, G. B. ; de Britto, M. ; de Freitas Souza, L. ; Solé, D. ; Amarales, L. ; Aguilar, P. ; Calvo, M. A. ; Soto-Quirós, M. E. ; Romieu, I. ; Cukier, G. ; Guggiari-Chase, J. A. ; Chiarella, P. ; Holgado, D. ; Howitt, M. E. ; Sears, M. ; Rennie, D. ; Yeatts, K. ; Redding, G. J. ; Priftanji, A. ; Riikjärv, M. A. ; Pekkanen, J. ; Gotua, M. ; Svabe, V. ; Kudzyte, J. ; Lis, G. ; Breborowicz, A. ; Deleanu, D. ; Kondiourina, E. G. ; Vogt, H. ; Ognev, V. ; Marks, G. ; Moyes, C. ; Pattemore, P. ; Mackay, R. ; Haidinger, G. ; Weyler, J. ; Standring, P. ; Goulding, R. ; Steriu, A. ; Bonci, E. ; Galassi, C. ; Petronio, M. G. ; Chellini, E. ; Bisanti, L. ; Sestini, P. ; Ciccone, G. ; Piffer, S. ; Camâra, R. ; Rosado Pinto, J. E. ; Nunes, C. ; dos Santos, J. M Lopes ; Clancy, L. ; Busquets, R. M. ; González Díaz, C. ; Arnedo-Pena, A. ; Garcia Hernández, G. ; Guillén-Grima, F. ; Morales-Suarez-Varela, M. M. ; Blanco Quirós, A. ; Thames, North ; Austin, J. B. ; Shamssain, M. H. ; Strachan, D. ; Burr, M. ; Shah, J. ; Baratawidjaja, K. ; Nishima, S. ; Baeza-Bacab, M. ; Manning, P. ; Khaitov, R. M. ; Lee, B. ; Nilsson, L. / The impact of the method of consent on response rates in the ISAAC time trends study. In: International Journal of Tuberculosis and Lung Disease. 2010 ; Vol. 14, No. 8. pp. 1059-1065.
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title = "The impact of the method of consent on response rates in the ISAAC time trends study",
abstract = "BACKGROUND: Centres in Phases I and III of the International Study of Asthma and Allergies in Childhood (ISAAC) programme used the method of consent (passive or active) required by local ethics committees. METHODS: Retrospectively, relationships between achieved response rates and method of consent for 13-14 and 6-7-year-olds (adolescents and children, respectively), were examined between phases and between English and non-English language centres. RESULTS: Information was obtained for 113 of 115 centres for adolescents and 72/72 centres for children. Both age groups: most centres using passive consent achieved high response rates (>80{\%} adolescents and >70{\%} children). English language centres using active consent showed a larger decrease in response rate. Adolescents: seven centres changed from passive consent in Phase I to active consent in Phase III (median decrease of 13{\%}), with five centres showing lower response rates (as low as 34{\%}). Children: no centre changed consent method between phases. Centres using active consent had lower median response rates (lowest response rate 45{\%}). CONCLUSION: The requirement for active consent for population school-based questionnaire studies can impact negatively on response rates, particularly English language centres, thus adversely affecting the validity of the data. Ethics committees need to consider this issue carefully.",
keywords = "Asthma, Children, Consent, Epidemiology, ISAAC",
author = "Philippa Ellwood and Asher, {M. I.} and Stewart, {A. W.} and N. A{\"i}t-Khaled and Anderson, {H. R.} and R. Beasley and B. Bj{\"o}rkst{\'e}n and B. Brunekreef and J. Crane and C. Flohr and S. Foliaki and F. Forastiere and L. Garc{\'i}a-Marcos and U. Keil and Lai, {C. K W} and J. Mallol and Mitchell, {E. A.} and S. Montefort and J. Odhiambo and N. Pearce and Robertson, {C. F.} and D. Strachan and {von Mutius}, E. and Weiland, {S. K.} and G. Weinmayr and H. Williams and G. Wong and Clayton, {T. O.} and B. Benhabyl{\`e}s and Esamai, {F. O.} and L. Ng'ang'a and Z. Bouayad and Onadeko, {B. O.} and Zar, {H. J.} and M. Jerray and Chen, {Y. Z.} and Zhong, {N. S.} and Lau, {Y. L.} and Kartasasmita, {C. B.} and H. Odajima and Teh, {K. H.} and {de Bruyne}, J. and Quah, {B. S.} and F. Cua-Lim and Goh, {D. Y T} and Lee, {H. B.} and Huang, {J. L.} and P. Vichyanond and M. Trakultivakom and Masjedi, {M. R.} and al-Momen, {J. A.} and N. Mahmood and O. Al-Rawas and Khatav, {V. A.} and L. Kumar and G. Setty and Jain, {K. C.} and Sukumaran, {T. U.} and Joshi, {M. K.} and Pherwani, {A. V.} and Sharma, {S. K.} and Hanumante, {N. M.} and Guimaraes, {I. M E} and Baena-Cagnani, {C. E.} and N. Ros{\'a}rio and Fischer, {G. B.} and {de Britto}, M. and {de Freitas Souza}, L. and D. Sol{\'e} and L. Amarales and P. Aguilar and Calvo, {M. A.} and Soto-Quir{\'o}s, {M. E.} and I. Romieu and G. Cukier and Guggiari-Chase, {J. A.} and P. Chiarella and D. Holgado and Howitt, {M. E.} and M. Sears and D. Rennie and K. Yeatts and Redding, {G. J.} and A. Priftanji and Riikj{\"a}rv, {M. A.} and J. Pekkanen and M. Gotua and V. Svabe and J. Kudzyte and G. Lis and A. Breborowicz and D. Deleanu and Kondiourina, {E. G.} and H. Vogt and V. Ognev and G. Marks and C. Moyes and P. Pattemore and R. Mackay and G. Haidinger and J. Weyler and P. Standring and R. Goulding and A. Steriu and E. Bonci and C. Galassi and Petronio, {M. G.} and E. Chellini and L. Bisanti and P. Sestini and G. Ciccone and S. Piffer and R. Cam{\^a}ra and {Rosado Pinto}, {J. E.} and C. Nunes and {dos Santos}, {J. M Lopes} and L. Clancy and Busquets, {R. M.} and {Gonz{\'a}lez D{\'i}az}, C. and A. Arnedo-Pena and {Garcia Hern{\'a}ndez}, G. and F. Guill{\'e}n-Grima and Morales-Suarez-Varela, {M. M.} and {Blanco Quir{\'o}s}, A. and North Thames and Austin, {J. B.} and Shamssain, {M. H.} and D. Strachan and M. Burr and J. Shah and K. Baratawidjaja and S. Nishima and M. Baeza-Bacab and P. Manning and Khaitov, {R. M.} and B. Lee and L. Nilsson",
year = "2010",
language = "English",
volume = "14",
pages = "1059--1065",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "8",

}

TY - JOUR

T1 - The impact of the method of consent on response rates in the ISAAC time trends study

AU - Ellwood, Philippa

AU - Asher, M. I.

AU - Stewart, A. W.

AU - Aït-Khaled, N.

AU - Anderson, H. R.

AU - Beasley, R.

AU - Björkstén, B.

AU - Brunekreef, B.

AU - Crane, J.

AU - Flohr, C.

AU - Foliaki, S.

AU - Forastiere, F.

AU - García-Marcos, L.

AU - Keil, U.

AU - Lai, C. K W

AU - Mallol, J.

AU - Mitchell, E. A.

AU - Montefort, S.

AU - Odhiambo, J.

AU - Pearce, N.

AU - Robertson, C. F.

AU - Strachan, D.

AU - von Mutius, E.

AU - Weiland, S. K.

AU - Weinmayr, G.

AU - Williams, H.

AU - Wong, G.

AU - Clayton, T. O.

AU - Benhabylès, B.

AU - Esamai, F. O.

AU - Ng'ang'a, L.

AU - Bouayad, Z.

AU - Onadeko, B. O.

AU - Zar, H. J.

AU - Jerray, M.

AU - Chen, Y. Z.

AU - Zhong, N. S.

AU - Lau, Y. L.

AU - Kartasasmita, C. B.

AU - Odajima, H.

AU - Teh, K. H.

AU - de Bruyne, J.

AU - Quah, B. S.

AU - Cua-Lim, F.

AU - Goh, D. Y T

AU - Lee, H. B.

AU - Huang, J. L.

AU - Vichyanond, P.

AU - Trakultivakom, M.

AU - Masjedi, M. R.

AU - al-Momen, J. A.

AU - Mahmood, N.

AU - Al-Rawas, O.

AU - Khatav, V. A.

AU - Kumar, L.

AU - Setty, G.

AU - Jain, K. C.

AU - Sukumaran, T. U.

AU - Joshi, M. K.

AU - Pherwani, A. V.

AU - Sharma, S. K.

AU - Hanumante, N. M.

AU - Guimaraes, I. M E

AU - Baena-Cagnani, C. E.

AU - Rosário, N.

AU - Fischer, G. B.

AU - de Britto, M.

AU - de Freitas Souza, L.

AU - Solé, D.

AU - Amarales, L.

AU - Aguilar, P.

AU - Calvo, M. A.

AU - Soto-Quirós, M. E.

AU - Romieu, I.

AU - Cukier, G.

AU - Guggiari-Chase, J. A.

AU - Chiarella, P.

AU - Holgado, D.

AU - Howitt, M. E.

AU - Sears, M.

AU - Rennie, D.

AU - Yeatts, K.

AU - Redding, G. J.

AU - Priftanji, A.

AU - Riikjärv, M. A.

AU - Pekkanen, J.

AU - Gotua, M.

AU - Svabe, V.

AU - Kudzyte, J.

AU - Lis, G.

AU - Breborowicz, A.

AU - Deleanu, D.

AU - Kondiourina, E. G.

AU - Vogt, H.

AU - Ognev, V.

AU - Marks, G.

AU - Moyes, C.

AU - Pattemore, P.

AU - Mackay, R.

AU - Haidinger, G.

AU - Weyler, J.

AU - Standring, P.

AU - Goulding, R.

AU - Steriu, A.

AU - Bonci, E.

AU - Galassi, C.

AU - Petronio, M. G.

AU - Chellini, E.

AU - Bisanti, L.

AU - Sestini, P.

AU - Ciccone, G.

AU - Piffer, S.

AU - Camâra, R.

AU - Rosado Pinto, J. E.

AU - Nunes, C.

AU - dos Santos, J. M Lopes

AU - Clancy, L.

AU - Busquets, R. M.

AU - González Díaz, C.

AU - Arnedo-Pena, A.

AU - Garcia Hernández, G.

AU - Guillén-Grima, F.

AU - Morales-Suarez-Varela, M. M.

AU - Blanco Quirós, A.

AU - Thames, North

AU - Austin, J. B.

AU - Shamssain, M. H.

AU - Strachan, D.

AU - Burr, M.

AU - Shah, J.

AU - Baratawidjaja, K.

AU - Nishima, S.

AU - Baeza-Bacab, M.

AU - Manning, P.

AU - Khaitov, R. M.

AU - Lee, B.

AU - Nilsson, L.

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Centres in Phases I and III of the International Study of Asthma and Allergies in Childhood (ISAAC) programme used the method of consent (passive or active) required by local ethics committees. METHODS: Retrospectively, relationships between achieved response rates and method of consent for 13-14 and 6-7-year-olds (adolescents and children, respectively), were examined between phases and between English and non-English language centres. RESULTS: Information was obtained for 113 of 115 centres for adolescents and 72/72 centres for children. Both age groups: most centres using passive consent achieved high response rates (>80% adolescents and >70% children). English language centres using active consent showed a larger decrease in response rate. Adolescents: seven centres changed from passive consent in Phase I to active consent in Phase III (median decrease of 13%), with five centres showing lower response rates (as low as 34%). Children: no centre changed consent method between phases. Centres using active consent had lower median response rates (lowest response rate 45%). CONCLUSION: The requirement for active consent for population school-based questionnaire studies can impact negatively on response rates, particularly English language centres, thus adversely affecting the validity of the data. Ethics committees need to consider this issue carefully.

AB - BACKGROUND: Centres in Phases I and III of the International Study of Asthma and Allergies in Childhood (ISAAC) programme used the method of consent (passive or active) required by local ethics committees. METHODS: Retrospectively, relationships between achieved response rates and method of consent for 13-14 and 6-7-year-olds (adolescents and children, respectively), were examined between phases and between English and non-English language centres. RESULTS: Information was obtained for 113 of 115 centres for adolescents and 72/72 centres for children. Both age groups: most centres using passive consent achieved high response rates (>80% adolescents and >70% children). English language centres using active consent showed a larger decrease in response rate. Adolescents: seven centres changed from passive consent in Phase I to active consent in Phase III (median decrease of 13%), with five centres showing lower response rates (as low as 34%). Children: no centre changed consent method between phases. Centres using active consent had lower median response rates (lowest response rate 45%). CONCLUSION: The requirement for active consent for population school-based questionnaire studies can impact negatively on response rates, particularly English language centres, thus adversely affecting the validity of the data. Ethics committees need to consider this issue carefully.

KW - Asthma

KW - Children

KW - Consent

KW - Epidemiology

KW - ISAAC

UR - http://www.scopus.com/inward/record.url?scp=77954710537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954710537&partnerID=8YFLogxK

M3 - Article

C2 - 20626953

AN - SCOPUS:77954710537

VL - 14

SP - 1059

EP - 1065

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 8

ER -