The ICET-A recommendations for the diagnosis and management of disturbances of glucose homeostasis in thalassemia major patients

Vincenzo De Sanctis, Ashraf T. Soliman, Heba Elsedfy, Saif Al Yaarubi, Nicos Skordis, Doaa Khater, Mohamed El Kholy, Iva Stoeva, Bernadette Fiscina, Michael Angastiniotis, Shahina Daar, Christos Kattamis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Iron overload in patients with thalassemia major (TM) affects glucose regulation and is mediated by several mechanisms. The pathogenesis of glycaemic abnormalities in TM is complex and multifactorial. It has been predominantly attributed to a combination of reduced insulin secretory capacity and insulin resistance. The exact mechanisms responsible for progression from norm glycaemia to overt diabetes in these patients are still poorly understood but are attributed mainly to insulin deficiency resulting from the toxic effects of iron deposited in the pancreas and insulin resistance. A group of endocrinologists, haematologists and paediatricians, members of the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A) convened to formulate recommendations for the diagnosis and management of abnormalities of glucose homeostasis in thalassemia major patients on the basis of available evidence from clinical and laboratory data and consensus practice. The results of their work and discussions are described in this article.

Original languageEnglish
Article numbere2016058
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume8
Issue number1
DOIs
Publication statusPublished - 2016

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beta-Thalassemia
Homeostasis
Glucose
Insulin Resistance
Insulin
Iron Overload
Thalassemia
Poisons
Pancreas
Iron
Medicine

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this

The ICET-A recommendations for the diagnosis and management of disturbances of glucose homeostasis in thalassemia major patients. / De Sanctis, Vincenzo; Soliman, Ashraf T.; Elsedfy, Heba; Al Yaarubi, Saif; Skordis, Nicos; Khater, Doaa; El Kholy, Mohamed; Stoeva, Iva; Fiscina, Bernadette; Angastiniotis, Michael; Daar, Shahina; Kattamis, Christos.

In: Mediterranean Journal of Hematology and Infectious Diseases, Vol. 8, No. 1, e2016058, 2016.

Research output: Contribution to journalArticle

De Sanctis, V, Soliman, AT, Elsedfy, H, Al Yaarubi, S, Skordis, N, Khater, D, El Kholy, M, Stoeva, I, Fiscina, B, Angastiniotis, M, Daar, S & Kattamis, C 2016, 'The ICET-A recommendations for the diagnosis and management of disturbances of glucose homeostasis in thalassemia major patients', Mediterranean Journal of Hematology and Infectious Diseases, vol. 8, no. 1, e2016058. https://doi.org/10.4084/MJHID.2016.058
De Sanctis, Vincenzo ; Soliman, Ashraf T. ; Elsedfy, Heba ; Al Yaarubi, Saif ; Skordis, Nicos ; Khater, Doaa ; El Kholy, Mohamed ; Stoeva, Iva ; Fiscina, Bernadette ; Angastiniotis, Michael ; Daar, Shahina ; Kattamis, Christos. / The ICET-A recommendations for the diagnosis and management of disturbances of glucose homeostasis in thalassemia major patients. In: Mediterranean Journal of Hematology and Infectious Diseases. 2016 ; Vol. 8, No. 1.
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