The haemopoietic stem cell: Between apoptosis and self renewal

Faris Q. Alenzi, Badi Q. Alenazi, Shamweel Y. Ahmad, Mohamed L. Salem, Ali A. Al-Jabri, Richard K H Wyse

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Self renewal and apoptosis of haemopoietic stem cells (HSC+) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role of HSC, there is still very little information on the mechanisms that govern HSC self renewal and apoptosis. Considerable insight into the role of HSC in many diseases has been gained in recent years. In light of their crucial importance, this article reviews recent developments in the understanding of the molecular, biological, and physiological characteristics of haemopoietic stem cells.

Original languageEnglish
Pages (from-to)7-18
Number of pages12
JournalYale Journal of Biology and Medicine
Volume82
Issue number1
Publication statusPublished - Mar 2009

Fingerprint

Stem cells
Stem Cells
Apoptosis
Cell Size
Bone
Bone Marrow
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Alenzi, F. Q., Alenazi, B. Q., Ahmad, S. Y., Salem, M. L., Al-Jabri, A. A., & Wyse, R. K. H. (2009). The haemopoietic stem cell: Between apoptosis and self renewal. Yale Journal of Biology and Medicine, 82(1), 7-18.

The haemopoietic stem cell : Between apoptosis and self renewal. / Alenzi, Faris Q.; Alenazi, Badi Q.; Ahmad, Shamweel Y.; Salem, Mohamed L.; Al-Jabri, Ali A.; Wyse, Richard K H.

In: Yale Journal of Biology and Medicine, Vol. 82, No. 1, 03.2009, p. 7-18.

Research output: Contribution to journalArticle

Alenzi, FQ, Alenazi, BQ, Ahmad, SY, Salem, ML, Al-Jabri, AA & Wyse, RKH 2009, 'The haemopoietic stem cell: Between apoptosis and self renewal', Yale Journal of Biology and Medicine, vol. 82, no. 1, pp. 7-18.
Alenzi FQ, Alenazi BQ, Ahmad SY, Salem ML, Al-Jabri AA, Wyse RKH. The haemopoietic stem cell: Between apoptosis and self renewal. Yale Journal of Biology and Medicine. 2009 Mar;82(1):7-18.
Alenzi, Faris Q. ; Alenazi, Badi Q. ; Ahmad, Shamweel Y. ; Salem, Mohamed L. ; Al-Jabri, Ali A. ; Wyse, Richard K H. / The haemopoietic stem cell : Between apoptosis and self renewal. In: Yale Journal of Biology and Medicine. 2009 ; Vol. 82, No. 1. pp. 7-18.
@article{e87c766dcab84d9ba62dbdd9ca77c66a,
title = "The haemopoietic stem cell: Between apoptosis and self renewal",
abstract = "Self renewal and apoptosis of haemopoietic stem cells (HSC+) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role of HSC, there is still very little information on the mechanisms that govern HSC self renewal and apoptosis. Considerable insight into the role of HSC in many diseases has been gained in recent years. In light of their crucial importance, this article reviews recent developments in the understanding of the molecular, biological, and physiological characteristics of haemopoietic stem cells.",
author = "Alenzi, {Faris Q.} and Alenazi, {Badi Q.} and Ahmad, {Shamweel Y.} and Salem, {Mohamed L.} and Al-Jabri, {Ali A.} and Wyse, {Richard K H}",
year = "2009",
month = "3",
language = "English",
volume = "82",
pages = "7--18",
journal = "Yale Journal of Biology and Medicine",
issn = "0044-0086",
publisher = "Yale Journal of Biology and Medicine Inc.",
number = "1",

}

TY - JOUR

T1 - The haemopoietic stem cell

T2 - Between apoptosis and self renewal

AU - Alenzi, Faris Q.

AU - Alenazi, Badi Q.

AU - Ahmad, Shamweel Y.

AU - Salem, Mohamed L.

AU - Al-Jabri, Ali A.

AU - Wyse, Richard K H

PY - 2009/3

Y1 - 2009/3

N2 - Self renewal and apoptosis of haemopoietic stem cells (HSC+) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role of HSC, there is still very little information on the mechanisms that govern HSC self renewal and apoptosis. Considerable insight into the role of HSC in many diseases has been gained in recent years. In light of their crucial importance, this article reviews recent developments in the understanding of the molecular, biological, and physiological characteristics of haemopoietic stem cells.

AB - Self renewal and apoptosis of haemopoietic stem cells (HSC+) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role of HSC, there is still very little information on the mechanisms that govern HSC self renewal and apoptosis. Considerable insight into the role of HSC in many diseases has been gained in recent years. In light of their crucial importance, this article reviews recent developments in the understanding of the molecular, biological, and physiological characteristics of haemopoietic stem cells.

UR - http://www.scopus.com/inward/record.url?scp=64949121713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64949121713&partnerID=8YFLogxK

M3 - Article

C2 - 19325941

AN - SCOPUS:64949121713

VL - 82

SP - 7

EP - 18

JO - Yale Journal of Biology and Medicine

JF - Yale Journal of Biology and Medicine

SN - 0044-0086

IS - 1

ER -