The functional relevance of NK-cell-mediated upregulation of antigen-specific IgG2a responses

Crystal Y. Koh, Dorothy Yuan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have previously shown that activation of NK cells by poly(I:C) or tumor treatment of mice increases the level of antigen-specific IgG2a (1, 2). We have now assessed the functional relevance of this effect of the innate immune system on the specific immune response. We found that the increased IgG2a significantly augments antibody-dependent cellular cytotoxicity mediated by NK cells both in vivo and in vitro. Furthermore, we show that both IgG3 producing plasma cells induced by T-independent antigens and IgG2a plasma cells induced in the presence of activated NK cells may be just as long-lived as plasma cells induced by T-dependent antigens. These results indicate that if NK cells are activated early in the immune response, before T cells are recruited, they could exert long-lasting effects. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalCellular Immunology
Volume204
Issue number2
DOIs
Publication statusPublished - Sep 15 2000

Fingerprint

Natural Killer Cells
Up-Regulation
Plasma Cells
Antigens
T Independent Antigens
Viral Tumor Antigens
Immune System
Immunoglobulin G
T-Lymphocytes
Antibodies
Neoplasms

Keywords

  • Antibodies
  • Cytotoxicity
  • Fc receptors
  • Ig half-lives
  • Isotypes
  • Murine
  • NK cells

ASJC Scopus subject areas

  • Immunology

Cite this

The functional relevance of NK-cell-mediated upregulation of antigen-specific IgG2a responses. / Koh, Crystal Y.; Yuan, Dorothy.

In: Cellular Immunology, Vol. 204, No. 2, 15.09.2000, p. 135-142.

Research output: Contribution to journalArticle

@article{25c3c311e7aa4d68abe7b8093e85d763,
title = "The functional relevance of NK-cell-mediated upregulation of antigen-specific IgG2a responses",
abstract = "We have previously shown that activation of NK cells by poly(I:C) or tumor treatment of mice increases the level of antigen-specific IgG2a (1, 2). We have now assessed the functional relevance of this effect of the innate immune system on the specific immune response. We found that the increased IgG2a significantly augments antibody-dependent cellular cytotoxicity mediated by NK cells both in vivo and in vitro. Furthermore, we show that both IgG3 producing plasma cells induced by T-independent antigens and IgG2a plasma cells induced in the presence of activated NK cells may be just as long-lived as plasma cells induced by T-dependent antigens. These results indicate that if NK cells are activated early in the immune response, before T cells are recruited, they could exert long-lasting effects. (C) 2000 Academic Press.",
keywords = "Antibodies, Cytotoxicity, Fc receptors, Ig half-lives, Isotypes, Murine, NK cells",
author = "Koh, {Crystal Y.} and Dorothy Yuan",
year = "2000",
month = "9",
day = "15",
doi = "10.1006/cimm.2000.1703",
language = "English",
volume = "204",
pages = "135--142",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - The functional relevance of NK-cell-mediated upregulation of antigen-specific IgG2a responses

AU - Koh, Crystal Y.

AU - Yuan, Dorothy

PY - 2000/9/15

Y1 - 2000/9/15

N2 - We have previously shown that activation of NK cells by poly(I:C) or tumor treatment of mice increases the level of antigen-specific IgG2a (1, 2). We have now assessed the functional relevance of this effect of the innate immune system on the specific immune response. We found that the increased IgG2a significantly augments antibody-dependent cellular cytotoxicity mediated by NK cells both in vivo and in vitro. Furthermore, we show that both IgG3 producing plasma cells induced by T-independent antigens and IgG2a plasma cells induced in the presence of activated NK cells may be just as long-lived as plasma cells induced by T-dependent antigens. These results indicate that if NK cells are activated early in the immune response, before T cells are recruited, they could exert long-lasting effects. (C) 2000 Academic Press.

AB - We have previously shown that activation of NK cells by poly(I:C) or tumor treatment of mice increases the level of antigen-specific IgG2a (1, 2). We have now assessed the functional relevance of this effect of the innate immune system on the specific immune response. We found that the increased IgG2a significantly augments antibody-dependent cellular cytotoxicity mediated by NK cells both in vivo and in vitro. Furthermore, we show that both IgG3 producing plasma cells induced by T-independent antigens and IgG2a plasma cells induced in the presence of activated NK cells may be just as long-lived as plasma cells induced by T-dependent antigens. These results indicate that if NK cells are activated early in the immune response, before T cells are recruited, they could exert long-lasting effects. (C) 2000 Academic Press.

KW - Antibodies

KW - Cytotoxicity

KW - Fc receptors

KW - Ig half-lives

KW - Isotypes

KW - Murine

KW - NK cells

UR - http://www.scopus.com/inward/record.url?scp=0034664871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034664871&partnerID=8YFLogxK

U2 - 10.1006/cimm.2000.1703

DO - 10.1006/cimm.2000.1703

M3 - Article

C2 - 11069721

AN - SCOPUS:0034664871

VL - 204

SP - 135

EP - 142

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 2

ER -