The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro

E. G. Rowan, H. Vatanpour, B. L. Furman, A. L. Harvey, M. O M Tanira, P. Gopalakrishnakone

Research output: Contribution to journalArticle

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Abstract

The Indian red scorpion Buthus tamulus (or Mesobuthus tamulus) can cause fatal envenoming, but its mechanism of action is unclear. Venom was tested in vivo in anaesthetized rats and in vitro on isolated cardiac and skeletal muscle preparations. In vivo, the venom caused marked rhythmical fluctuations in blood pressure preceding cardiovascular collapse and death. On sheep Purkinje fibres, venom could induce spontaneous action potentials and cause prolongation of action potential duration. In chick biventer cervicis and mouse triangularis sterni preparations, venom enhanced the release of acetylcholine and induced repetitive firing of nerve action potentials in response to single shock stimulation. High concentrations caused stimulation then block of neuromuscular transmission. The main effects of Buthus tamulus venom are likely to be due to toxins that affect the opening of Na+ channels in nerves and muscles. This will cause an increase in the release of neurotransmitters in the peripheral nervous system, which may produce cardiovascular abnormalities and respiratory paralysis.

Original languageEnglish
Pages (from-to)1157-1164
Number of pages8
JournalToxicon
Volume30
Issue number10
DOIs
Publication statusPublished - 1992

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Scorpions
Venoms
Action Potentials
Muscle
Respiratory Paralysis
Cardiovascular Abnormalities
Purkinje Fibers
Neuromuscular Blockade
Blood pressure
Peripheral Nervous System
Neurology
Acetylcholine
Neurotransmitter Agents
Rats
Shock
Sheep
Myocardium
Skeletal Muscle
In Vitro Techniques
Blood Pressure

ASJC Scopus subject areas

  • Toxicology

Cite this

Rowan, E. G., Vatanpour, H., Furman, B. L., Harvey, A. L., Tanira, M. O. M., & Gopalakrishnakone, P. (1992). The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro. Toxicon, 30(10), 1157-1164. https://doi.org/10.1016/0041-0101(92)90431-4

The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro. / Rowan, E. G.; Vatanpour, H.; Furman, B. L.; Harvey, A. L.; Tanira, M. O M; Gopalakrishnakone, P.

In: Toxicon, Vol. 30, No. 10, 1992, p. 1157-1164.

Research output: Contribution to journalArticle

Rowan, EG, Vatanpour, H, Furman, BL, Harvey, AL, Tanira, MOM & Gopalakrishnakone, P 1992, 'The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro', Toxicon, vol. 30, no. 10, pp. 1157-1164. https://doi.org/10.1016/0041-0101(92)90431-4
Rowan EG, Vatanpour H, Furman BL, Harvey AL, Tanira MOM, Gopalakrishnakone P. The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro. Toxicon. 1992;30(10):1157-1164. https://doi.org/10.1016/0041-0101(92)90431-4
Rowan, E. G. ; Vatanpour, H. ; Furman, B. L. ; Harvey, A. L. ; Tanira, M. O M ; Gopalakrishnakone, P. / The effects of Indian red scorpion Buthus tamulus venom in vivo and in vitro. In: Toxicon. 1992 ; Vol. 30, No. 10. pp. 1157-1164.
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