The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver

H. A. Elsheikh, B. H. Ali, A. M. Homeida, A. A A Lutfi, H. J. Hapke

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Desert sheep experimentally or naturally infected with Fasciola gigantica were used to study the influence of infection on the activities of some drug-metabolizing enzymes found in the liver. The enzymes investigated were aminopyrine N-demethylase, aniline 4-hydroxylase and UDP-glucuronyltransferase. The experimental infection was confirmed histologically by detection of Fasciola eggs in faeces and by measuring the activities of sorbitol dehydrogenase (SD), glutamate dehydrogenase (GD) and aspartate aminotransferase (AST) in plasma during the course of the disease. Liver specimens from naturally infected sheep were obtained from the slaughter house. The activities of aminopyrine N-demethylase and aniline 4-hydroxylase were significantly decreased in sheep either naturally infected or during the acute stage of experimental fascioliasis (killed 5 weeks post-infection). The activity of UDP-glucuronyltransferase was decreased in naturally infected sheep and those killed 9 or 13 weeks post-experimental infection.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalBritish Veterinary Journal
Volume148
Issue number3
DOIs
Publication statusPublished - 1992

Fingerprint

Fascioliasis
fascioliasis
deserts
Sheep
Aminopyrine N-Demethylase
Aniline Hydroxylase
Fasciola
sheep
drugs
Glucuronosyltransferase
liver
aniline
Liver
Enzymes
enzymes
Infection
infection
Pharmaceutical Preparations
L-iditol dehydrogenase
L-Iditol 2-Dehydrogenase

ASJC Scopus subject areas

  • veterinary(all)

Cite this

The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver. / Elsheikh, H. A.; Ali, B. H.; Homeida, A. M.; Lutfi, A. A A; Hapke, H. J.

In: British Veterinary Journal, Vol. 148, No. 3, 1992, p. 249-257.

Research output: Contribution to journalArticle

Elsheikh, H. A. ; Ali, B. H. ; Homeida, A. M. ; Lutfi, A. A A ; Hapke, H. J. / The effects of fascioliasis on the activities of some drug-metabolizing enzymes in desert sheep liver. In: British Veterinary Journal. 1992 ; Vol. 148, No. 3. pp. 249-257.
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