Abstract
Background: Psoriasis is a genetically determined inflammatory skin disease. It is now recognized that narrow band TL-01 phototherapy is an effective treatment for psoriasis. However, ultraviolet (UV) exposure induces p53 mutations in keratinocytes and repeated exposure of skin to UV radiation results in clonal expansion of these initiated p53-mutant cells within the epidermis. Aim: The present study aims to examine epidermal p53 expression in the skin of psoriatic patients at different time points following TL-01 phototherapy. Methods: Skin samples from patients suffering from plaque-type psoriasis, collected before, during and at the final stages of TL-01 phototherapy were examined for p53 expression by immunohistochemistry. Results/Conclusion: Our results showed an increase in p53 expressing keratinocytes following TL-01 phototherapy. Some of these cells were arranged spatially, as conical clones arising from putative stem cell compartments, suggesting that the chronic TL-01 treatment might have triggered cell growth and clonal expansion, an important step in initiating skin carcinogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 12-17 |
| Number of pages | 6 |
| Journal | Photodermatology Photoimmunology and Photomedicine |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2006 |
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Keywords
- Apoptosis
- p53 expression
- Phototherapy
- Psoriasis
- Skin cancer
- TL-01
ASJC Scopus subject areas
- Dermatology
- Immunology
Cite this
The effect of ultra violet B (TL-01) phototherapy on epidermal expression of p53 protein in psoriatic plaques. / Jasim, Z. F.; Lioe, T. F.; McKenna, K. E.; Robson, T.; Ouhtit, Allal.
In: Photodermatology Photoimmunology and Photomedicine, Vol. 22, No. 1, 02.2006, p. 12-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of ultra violet B (TL-01) phototherapy on epidermal expression of p53 protein in psoriatic plaques
AU - Jasim, Z. F.
AU - Lioe, T. F.
AU - McKenna, K. E.
AU - Robson, T.
AU - Ouhtit, Allal
PY - 2006/2
Y1 - 2006/2
N2 - Background: Psoriasis is a genetically determined inflammatory skin disease. It is now recognized that narrow band TL-01 phototherapy is an effective treatment for psoriasis. However, ultraviolet (UV) exposure induces p53 mutations in keratinocytes and repeated exposure of skin to UV radiation results in clonal expansion of these initiated p53-mutant cells within the epidermis. Aim: The present study aims to examine epidermal p53 expression in the skin of psoriatic patients at different time points following TL-01 phototherapy. Methods: Skin samples from patients suffering from plaque-type psoriasis, collected before, during and at the final stages of TL-01 phototherapy were examined for p53 expression by immunohistochemistry. Results/Conclusion: Our results showed an increase in p53 expressing keratinocytes following TL-01 phototherapy. Some of these cells were arranged spatially, as conical clones arising from putative stem cell compartments, suggesting that the chronic TL-01 treatment might have triggered cell growth and clonal expansion, an important step in initiating skin carcinogenesis.
AB - Background: Psoriasis is a genetically determined inflammatory skin disease. It is now recognized that narrow band TL-01 phototherapy is an effective treatment for psoriasis. However, ultraviolet (UV) exposure induces p53 mutations in keratinocytes and repeated exposure of skin to UV radiation results in clonal expansion of these initiated p53-mutant cells within the epidermis. Aim: The present study aims to examine epidermal p53 expression in the skin of psoriatic patients at different time points following TL-01 phototherapy. Methods: Skin samples from patients suffering from plaque-type psoriasis, collected before, during and at the final stages of TL-01 phototherapy were examined for p53 expression by immunohistochemistry. Results/Conclusion: Our results showed an increase in p53 expressing keratinocytes following TL-01 phototherapy. Some of these cells were arranged spatially, as conical clones arising from putative stem cell compartments, suggesting that the chronic TL-01 treatment might have triggered cell growth and clonal expansion, an important step in initiating skin carcinogenesis.
KW - Apoptosis
KW - p53 expression
KW - Phototherapy
KW - Psoriasis
KW - Skin cancer
KW - TL-01
UR - http://www.scopus.com/inward/record.url?scp=33646678466&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646678466&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0781.2006.00197.x
DO - 10.1111/j.1600-0781.2006.00197.x
M3 - Article
VL - 22
SP - 12
EP - 17
JO - Photodermatology Photoimmunology and Photomedicine
JF - Photodermatology Photoimmunology and Photomedicine
SN - 0905-4383
IS - 1
ER -