TY - JOUR
T1 - The effect of residing altitude on levels of high-density lipoprotein cholesterol
T2 - A pilot study from the Omani Arab population
AU - Al Riyami, Nafila B.
AU - Banerjee, Yajnavalka
AU - Al-Waili, Khalid
AU - Rizvi, Syed G.
AU - Al-Yahyaee, Said
AU - Hassan, Mohammed O.
AU - Albarwani, Sulayma
AU - Al-Rasadi, Khalid
AU - Bayoumi, Riad A.
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2015/7/19
Y1 - 2015/7/19
N2 - Lower mortality rates from coronary heart disease and higher levels of serum high-density lipoprotein cholesterol (HDL-C) have been observed in populations residing at high altitude. However, this effect has not been investigated in Arab populations, which exhibit considerable genetic homogeneity. We assessed the relationship between residing altitude and HDL-C in 2 genetically similar Omani Arab populations residing at different altitudes. The association between the levels of HDL-C and other metabolic parameters was also investigated. The levels of HDL-C were significantly higher in the high-altitude group compared with the low-altitude group. Stepwise regression analysis showed that altitude was the most significant factor affecting HDL-C, followed by gender, serum triglycerides, and finally the 2-hour postprandial plasma glucose. This finding is consistent with previously published studies from other populations and should be taken into consideration when comparing cardiovascular risk factors in populations residing at different altitudes.
AB - Lower mortality rates from coronary heart disease and higher levels of serum high-density lipoprotein cholesterol (HDL-C) have been observed in populations residing at high altitude. However, this effect has not been investigated in Arab populations, which exhibit considerable genetic homogeneity. We assessed the relationship between residing altitude and HDL-C in 2 genetically similar Omani Arab populations residing at different altitudes. The association between the levels of HDL-C and other metabolic parameters was also investigated. The levels of HDL-C were significantly higher in the high-altitude group compared with the low-altitude group. Stepwise regression analysis showed that altitude was the most significant factor affecting HDL-C, followed by gender, serum triglycerides, and finally the 2-hour postprandial plasma glucose. This finding is consistent with previously published studies from other populations and should be taken into consideration when comparing cardiovascular risk factors in populations residing at different altitudes.
KW - Arab
KW - Oman
KW - altitude
KW - high-density lipoprotein cholesterol
KW - metabolic parameters
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U2 - 10.1177/0003319714544355
DO - 10.1177/0003319714544355
M3 - Article
C2 - 25078070
AN - SCOPUS:84931098896
SN - 0003-3197
VL - 66
SP - 568
EP - 573
JO - Angiology
JF - Angiology
IS - 6
ER -