The effect of residing altitude on levels of high-density lipoprotein cholesterol: A pilot study from the Omani Arab population

Nafila B. Al Riyami, Yajnavalka Banerjee, Khalid Al-Waili, Syed G. Rizvi, Said Al-Yahyaee, Mohammed O. Hassan, Sulayma Albarwani, Khalid Al-Rasadi, Riad A. Bayoumi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lower mortality rates from coronary heart disease and higher levels of serum high-density lipoprotein cholesterol (HDL-C) have been observed in populations residing at high altitude. However, this effect has not been investigated in Arab populations, which exhibit considerable genetic homogeneity. We assessed the relationship between residing altitude and HDL-C in 2 genetically similar Omani Arab populations residing at different altitudes. The association between the levels of HDL-C and other metabolic parameters was also investigated. The levels of HDL-C were significantly higher in the high-altitude group compared with the low-altitude group. Stepwise regression analysis showed that altitude was the most significant factor affecting HDL-C, followed by gender, serum triglycerides, and finally the 2-hour postprandial plasma glucose. This finding is consistent with previously published studies from other populations and should be taken into consideration when comparing cardiovascular risk factors in populations residing at different altitudes.

Original languageEnglish
Pages (from-to)568-573
Number of pages6
JournalAngiology
Volume66
Issue number6
DOIs
Publication statusPublished - Jul 19 2015

    Fingerprint

Keywords

  • altitude
  • Arab
  • high-density lipoprotein cholesterol
  • metabolic parameters
  • Oman

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this