The effect of nitrofurazone on the thiamin status of chickens

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. 1. Nitrofurazone, given orally at doses of 10 and 20 mg/kg for seven days, decreased the activity of erythrocyte transketolase (TK) and increased the activation of TK by thiamin pyrophosphate (TPP effect %). 2. 2. Nitrofurazone also decreased the feed intake and growth of the chickens, and increased the concentrations of lactate and pyruvate of their blood. 3. 3. It was concluded that nitrofurazone has induced thiamin deficiency in the treated birds. 4. 4. Pair-feeding experiments showed that the decreased growth was due to anorexia, and that the effects produced by nitrofurazone treatment on the thiamin status were attributable to the drug, per se, and not to anorexia. 5. 5. Thiamin (100 μg/kg, injected subcutaneously), when given concomitantly with nitrofurazone, was effective in preventing the development of thiamin deficiency.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume76
Issue number1
DOIs
Publication statusPublished - 1983

Fingerprint

Nitrofurazone
Thiamine
Chickens
Transketolase
Thiamine Deficiency
Anorexia
Thiamine Pyrophosphate
Growth
Pyruvic Acid
Birds
Lactic Acid
Erythrocytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

The effect of nitrofurazone on the thiamin status of chickens. / Ali, B. H.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 76, No. 1, 1983, p. 131-134.

Research output: Contribution to journalArticle

@article{3afbe20a7258483ba590e9dab1c6e399,
title = "The effect of nitrofurazone on the thiamin status of chickens",
abstract = "1. 1. Nitrofurazone, given orally at doses of 10 and 20 mg/kg for seven days, decreased the activity of erythrocyte transketolase (TK) and increased the activation of TK by thiamin pyrophosphate (TPP effect {\%}). 2. 2. Nitrofurazone also decreased the feed intake and growth of the chickens, and increased the concentrations of lactate and pyruvate of their blood. 3. 3. It was concluded that nitrofurazone has induced thiamin deficiency in the treated birds. 4. 4. Pair-feeding experiments showed that the decreased growth was due to anorexia, and that the effects produced by nitrofurazone treatment on the thiamin status were attributable to the drug, per se, and not to anorexia. 5. 5. Thiamin (100 μg/kg, injected subcutaneously), when given concomitantly with nitrofurazone, was effective in preventing the development of thiamin deficiency.",
author = "Ali, {B. H.}",
year = "1983",
doi = "10.1016/0742-8413(83)90055-5",
language = "English",
volume = "76",
pages = "131--134",
journal = "Comparative biochemistry and physiology. C: Comparative pharmacology",
issn = "0306-4492",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - The effect of nitrofurazone on the thiamin status of chickens

AU - Ali, B. H.

PY - 1983

Y1 - 1983

N2 - 1. 1. Nitrofurazone, given orally at doses of 10 and 20 mg/kg for seven days, decreased the activity of erythrocyte transketolase (TK) and increased the activation of TK by thiamin pyrophosphate (TPP effect %). 2. 2. Nitrofurazone also decreased the feed intake and growth of the chickens, and increased the concentrations of lactate and pyruvate of their blood. 3. 3. It was concluded that nitrofurazone has induced thiamin deficiency in the treated birds. 4. 4. Pair-feeding experiments showed that the decreased growth was due to anorexia, and that the effects produced by nitrofurazone treatment on the thiamin status were attributable to the drug, per se, and not to anorexia. 5. 5. Thiamin (100 μg/kg, injected subcutaneously), when given concomitantly with nitrofurazone, was effective in preventing the development of thiamin deficiency.

AB - 1. 1. Nitrofurazone, given orally at doses of 10 and 20 mg/kg for seven days, decreased the activity of erythrocyte transketolase (TK) and increased the activation of TK by thiamin pyrophosphate (TPP effect %). 2. 2. Nitrofurazone also decreased the feed intake and growth of the chickens, and increased the concentrations of lactate and pyruvate of their blood. 3. 3. It was concluded that nitrofurazone has induced thiamin deficiency in the treated birds. 4. 4. Pair-feeding experiments showed that the decreased growth was due to anorexia, and that the effects produced by nitrofurazone treatment on the thiamin status were attributable to the drug, per se, and not to anorexia. 5. 5. Thiamin (100 μg/kg, injected subcutaneously), when given concomitantly with nitrofurazone, was effective in preventing the development of thiamin deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0021030575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021030575&partnerID=8YFLogxK

U2 - 10.1016/0742-8413(83)90055-5

DO - 10.1016/0742-8413(83)90055-5

M3 - Article

C2 - 6139240

AN - SCOPUS:0021030575

VL - 76

SP - 131

EP - 134

JO - Comparative biochemistry and physiology. C: Comparative pharmacology

JF - Comparative biochemistry and physiology. C: Comparative pharmacology

SN - 0306-4492

IS - 1

ER -