THE EFFECT OF IVERMECTIN ON SOME HAEMATOLOGICAL INDICES IN RABBITS: INFLUENCE OF VITAMIN K TREATMENT

B. H. Ali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, the drug reduced significantly the erythrocyte counts, haemoglobin concentration, haematocrit, mean corpuscular haemoglobin concentration and mean corpuscular haemoglobin on weeks 1, 2, 3 and 4. Platelet counts were not significantly affected. 2. In another trial, ivermectin was injected subcutaneously at a dose of 2.5 mg/kg, after pre‐treatment with either saline or vitamin K (30 μg/kg for 30 days), and prothrombin time, bleeding time and platelet counts measured at weekly intervals for 4 weeks. Bleeding time and thrombin time were significantly increased 1 week after treatment, and remained higher than the control for 4 weeks.

Original languageEnglish
Pages (from-to)735-738
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 1990
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'THE EFFECT OF IVERMECTIN ON SOME HAEMATOLOGICAL INDICES IN RABBITS: INFLUENCE OF VITAMIN K TREATMENT'. Together they form a unique fingerprint.

Cite this