The effect of furazolidone and furaltadone on drug metabolism in rats

B. H. Ali, M. O M Tanira, A. K. Bashir

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This work examines the effect of oral treatment of rats with the nitrofuran drugs furazolidone (FZ) and furaltadone (F) at doses of 100, 200 and 400 mg/kg for 4 days, or F in the drinking water at concentrations of 0.1, 0.2 and 0.4% w/v for 14 days, on drug metabolism in vivo. FZ at doses of 200 and 400 mg/kg, and F at a dose of 400 mg/kg or at a concentration of 0.4% w/v in water depressed growth and prolonged pentobarbitone-induced sleeping time. Treatment also significantly increased the blood concentration of metronidazole when measured 30 and 40 min after metronidazole administration. Administration of tremorine (25 mg/kg, i.p.) to control vehicle-treated rats produced within 2-3 min tremors, piloerection, profuse salivation, defecation urination and chromodacryorrhesis (red tears). The onset of appearance of these signs was delayed to 7-12 min in rats pretreated with FZ or F (100 mg/kg, 4 days) or cimetidine (50 mg/kg, i.p.) given 45 min earlier. Taken together, these results suggest that FZ and F inhibit drug metabolism in rats. Treatment with these nitrofuran drugs may alter the disposition of certain drugs which may be given concomitantly with them.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume21
Issue number4
Publication statusPublished - 1996

    Fingerprint

Keywords

  • Drug metabolism
  • Furaltadone
  • Furazolidone
  • Metronidazole
  • Tremorine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

Cite this