The Effect of Curcumin on Oxaliplatin and Cisplatin Neurotoxicity in Rats: Some Behavioral, Biochemical, and Histopathological Studies

Mansour S. Al Moundhri, Suhail Al-Salam, Ahmed Al Mahrouqee, S. Beegam, Badreldin H. Ali

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Cisplatin is commonly used against several solid tumors, and oxaliplatin is an effective cytotoxic drug used in colorectal cancer. A major clinical issue affecting 10-40 % of patients treated with cisplatin or oxaliplatin is severe peripheral neuropathy causing sensory, motor, and autonomic dysfunction, with symptoms including cold sensitivity and neuropathic pain. The biochemical basis of the neurotoxicity is uncertain, but is associated with oxidative stress. Curcumin (a natural phenolic yellow pigment) has strong antioxidant, anticancer, and anti-inflammatory actions. Here we report the possible protective effect of curcumin on some cisplatin- and oxaliplatin-induced behavioral, biochemical, and histopathological alterations in rats. Twenty-four hours after the end of treatments some motor and behavioral tests (motor activity, thermal and mechanical nociception, and neuromuscular coordination) were conducted, followed by measuring plasma neurotensin platinum concentration in the sciatic nerve, and studying the histopathology of the sciatic nerve. Oxaliplatin (4 mg/kg) and cisplatin (2 mg/kg) [each given twice weekly, in a total of nine intraperitoneal injections over 4. 5 weeks] significantly increased plasma neurotensin concentration, caused specific damage in the histology of the sciatic nerve and produced variable effects in the motor and behavioral tests. Oral curcumin (10 mg/kg, 4 days before the platinum drug, and thereafter, concomitantly with it for 4. 5 weeks) reversed the alterations in the plasma neurotensin and sciatic nerve platinum concentrations, and markedly improved sciatic nerve histology in the platinum-treated rats. Larger experiments using a wider dose range of oxaliplatin, cisplatin, and curcumin are required to fully elucidate the possible protective role of curcumin in platinum-induced neurotoxicity.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalJournal of Medical Toxicology
Volume9
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

oxaliplatin
Curcumin
Sciatic Nerve
Platinum
Cisplatin
Rats
Neurotensin
Histology
Plasmas
Oxidative stress
Nociception
Neuralgia
Peripheral Nervous System Diseases
Intraperitoneal Injections
Pigments
Pharmaceutical Preparations
Tumors
Colorectal Neoplasms
Motor Activity
Oxidative Stress

Keywords

  • Cisplatin
  • Curcumin
  • Neurotoxicity
  • Oxaliplatin
  • Rats

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

The Effect of Curcumin on Oxaliplatin and Cisplatin Neurotoxicity in Rats : Some Behavioral, Biochemical, and Histopathological Studies. / Al Moundhri, Mansour S.; Al-Salam, Suhail; Al Mahrouqee, Ahmed; Beegam, S.; Ali, Badreldin H.

In: Journal of Medical Toxicology, Vol. 9, No. 1, 2013, p. 25-33.

Research output: Contribution to journalArticle

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