The effect of chronic administration of cyclosporin A on phenytoin pharmacokinetic parameters in the rat

Ibrahim A. Wasfi, Musbah O M Tanira

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The potential for a drug interaction between cyclosporin A and phenytoin was investigated in rats. Rats were treated daily for 14 days with cyclosporin A (50mg/Kg, s.c.) and on the day of the experiment phenytoin (10mg/Kg) was administered intravenously. The mean residence time, the elimination half-life and the volume of distribution at steady state were significantly higher in the cyclosporin A-treated group than in the control group. However, total body clearance was similar in both groups. Plasma levels of urea, aspartate aminotransferase (AST) and glucose were significantly higher in the cyclosporin A-treated group than the control group. It was concluded that the observed changes could have been, at least in part, due to an inhibitory effect of cyclosporin A on liver drug metabolizing enzymes and/or liver and kidney damage.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalLife Sciences
Volume52
Issue number2
DOIs
Publication statusPublished - 1993

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Pharmacokinetics
Phenytoin
Cyclosporine
Rats
Liver
Drug interactions
Control Groups
Aspartate Aminotransferases
Drug Interactions
Half-Life
Urea
Kidney
Plasmas
Glucose
Enzymes
Pharmaceutical Preparations
Experiments

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of chronic administration of cyclosporin A on phenytoin pharmacokinetic parameters in the rat. / Wasfi, Ibrahim A.; Tanira, Musbah O M.

In: Life Sciences, Vol. 52, No. 2, 1993, p. 199-204.

Research output: Contribution to journalArticle

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