The Effect of a Synthetic Enkephalin Analogue on Postprandial Gastrointestinal and Pancreatic Hormone Secretion

S. N. Sullivan, S. R. Bloom, T. E. Adrian, L. Lamki, T. McDonald, P. Corcoran

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of the synthetic enkephalin analogue Sandoz FK33‐824 (DAMME) on gastric emptying and the postprandial secretion of upper gastrointestinal and pancreatic hormones was investigated in six healthy subjects. Gastric emptying was delayed as was the postprandial rise in glucose. There was significant blunting of insulin and gastric inhibitory polypeptide secretion, with complete abolition of the normal postprandial increases in pancreatic polypeptide and motilin. The secretion of gastrin was prolonged. These results demonstrate that pharmacological doses of opiate peptides inhibit gastric emptying and may have direct and indirect effects on gastrointestinal and pancreatic hormone secretion.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalThe American Journal of Gastroenterology
Volume78
Issue number5
DOIs
Publication statusPublished - 1983

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Pancreatic Hormones
Gastrointestinal Hormones
Enkephalins
Gastric Emptying
D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
Gastric Inhibitory Polypeptide
Motilin
Pancreatic Polypeptide
Opioid Peptides
Gastrins
Healthy Volunteers
Pharmacology
Insulin
Glucose

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The Effect of a Synthetic Enkephalin Analogue on Postprandial Gastrointestinal and Pancreatic Hormone Secretion. / Sullivan, S. N.; Bloom, S. R.; Adrian, T. E.; Lamki, L.; McDonald, T.; Corcoran, P.

In: The American Journal of Gastroenterology, Vol. 78, No. 5, 1983, p. 287-290.

Research output: Contribution to journalArticle

Sullivan, S. N. ; Bloom, S. R. ; Adrian, T. E. ; Lamki, L. ; McDonald, T. ; Corcoran, P. / The Effect of a Synthetic Enkephalin Analogue on Postprandial Gastrointestinal and Pancreatic Hormone Secretion. In: The American Journal of Gastroenterology. 1983 ; Vol. 78, No. 5. pp. 287-290.
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