The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells

Souheil Antoine Younes, Lydie Trautmann, Bader Yassine-Diab, Lena H. Kalfayan, Anne Elen Kernaleguen, Thomas O. Cameron, Rachid Boulassel, Lawrence J. Stern, Jean Pierre Routy, Zvi Grossman, Alain R. Dumont, Rafick Pierre Sekaly

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The impact of exposure to Ag on the development and maintenance of human CD4+ memory T cells in general and HIV infection in particular is partially understood. In this stedy, we measured HIV-specific CD4+ T cell proliferative responses against HIV proteins and derived peptides one year after highly active antiretroviral therapy initiation in 39 HIV-infected patients who initiated therapy at different times following infection. We show that a brief exposure to HIV of <1 month does not allow the generation of significant detectable frequencies of HIV-specific CD4+ memory T cells. Patients having prolonged cumulative exposure to high viral load due to therapy failures also demonstrated limited HIV-specific CD4+ T cell responses. In contrast, patients exposed to significant levels of virus for periods ranging from 3 to 18 mo showed brisk and broad HIV-specific CD4 + T cell responses 1 year following the onset of therapy intervention. We also demonstrate that the nadir CD4+ T cell count before therapy initiation correlated positively with the breadth and magnitude of these responses. Our findings indicate that the loss of proliferative HIV-specific CD4+ T cell responses is associated with the systemic progression of the disease and that a brief exposure to HIV does not allow the establishment of detectable frequencies of HIV-specific memory CD4+ T cells.

Original languageEnglish
Pages (from-to)788-797
Number of pages10
JournalJournal of Immunology
Volume178
Issue number2
Publication statusPublished - Jan 15 2007

Fingerprint

HIV
T-Lymphocytes
Human Immunodeficiency Virus Proteins
Highly Active Antiretroviral Therapy
Human Development
Therapeutics
CD4 Lymphocyte Count
Viral Load
HIV Infections
Disease Progression
Viruses
Peptides
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Younes, S. A., Trautmann, L., Yassine-Diab, B., Kalfayan, L. H., Kernaleguen, A. E., Cameron, T. O., ... Sekaly, R. P. (2007). The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. Journal of Immunology, 178(2), 788-797.

The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. / Younes, Souheil Antoine; Trautmann, Lydie; Yassine-Diab, Bader; Kalfayan, Lena H.; Kernaleguen, Anne Elen; Cameron, Thomas O.; Boulassel, Rachid; Stern, Lawrence J.; Routy, Jean Pierre; Grossman, Zvi; Dumont, Alain R.; Sekaly, Rafick Pierre.

In: Journal of Immunology, Vol. 178, No. 2, 15.01.2007, p. 788-797.

Research output: Contribution to journalArticle

Younes, SA, Trautmann, L, Yassine-Diab, B, Kalfayan, LH, Kernaleguen, AE, Cameron, TO, Boulassel, R, Stern, LJ, Routy, JP, Grossman, Z, Dumont, AR & Sekaly, RP 2007, 'The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells', Journal of Immunology, vol. 178, no. 2, pp. 788-797.
Younes SA, Trautmann L, Yassine-Diab B, Kalfayan LH, Kernaleguen AE, Cameron TO et al. The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. Journal of Immunology. 2007 Jan 15;178(2):788-797.
Younes, Souheil Antoine ; Trautmann, Lydie ; Yassine-Diab, Bader ; Kalfayan, Lena H. ; Kernaleguen, Anne Elen ; Cameron, Thomas O. ; Boulassel, Rachid ; Stern, Lawrence J. ; Routy, Jean Pierre ; Grossman, Zvi ; Dumont, Alain R. ; Sekaly, Rafick Pierre. / The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells. In: Journal of Immunology. 2007 ; Vol. 178, No. 2. pp. 788-797.
@article{3a1e6a3783384208a3eac86ba89d1919,
title = "The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells",
abstract = "The impact of exposure to Ag on the development and maintenance of human CD4+ memory T cells in general and HIV infection in particular is partially understood. In this stedy, we measured HIV-specific CD4+ T cell proliferative responses against HIV proteins and derived peptides one year after highly active antiretroviral therapy initiation in 39 HIV-infected patients who initiated therapy at different times following infection. We show that a brief exposure to HIV of <1 month does not allow the generation of significant detectable frequencies of HIV-specific CD4+ memory T cells. Patients having prolonged cumulative exposure to high viral load due to therapy failures also demonstrated limited HIV-specific CD4+ T cell responses. In contrast, patients exposed to significant levels of virus for periods ranging from 3 to 18 mo showed brisk and broad HIV-specific CD4 + T cell responses 1 year following the onset of therapy intervention. We also demonstrate that the nadir CD4+ T cell count before therapy initiation correlated positively with the breadth and magnitude of these responses. Our findings indicate that the loss of proliferative HIV-specific CD4+ T cell responses is associated with the systemic progression of the disease and that a brief exposure to HIV does not allow the establishment of detectable frequencies of HIV-specific memory CD4+ T cells.",
author = "Younes, {Souheil Antoine} and Lydie Trautmann and Bader Yassine-Diab and Kalfayan, {Lena H.} and Kernaleguen, {Anne Elen} and Cameron, {Thomas O.} and Rachid Boulassel and Stern, {Lawrence J.} and Routy, {Jean Pierre} and Zvi Grossman and Dumont, {Alain R.} and Sekaly, {Rafick Pierre}",
year = "2007",
month = "1",
day = "15",
language = "English",
volume = "178",
pages = "788--797",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "2",

}

TY - JOUR

T1 - The duration of exposure to HIV modulates the breadth and the magnitude of HIV-specific memory CD4+ T cells

AU - Younes, Souheil Antoine

AU - Trautmann, Lydie

AU - Yassine-Diab, Bader

AU - Kalfayan, Lena H.

AU - Kernaleguen, Anne Elen

AU - Cameron, Thomas O.

AU - Boulassel, Rachid

AU - Stern, Lawrence J.

AU - Routy, Jean Pierre

AU - Grossman, Zvi

AU - Dumont, Alain R.

AU - Sekaly, Rafick Pierre

PY - 2007/1/15

Y1 - 2007/1/15

N2 - The impact of exposure to Ag on the development and maintenance of human CD4+ memory T cells in general and HIV infection in particular is partially understood. In this stedy, we measured HIV-specific CD4+ T cell proliferative responses against HIV proteins and derived peptides one year after highly active antiretroviral therapy initiation in 39 HIV-infected patients who initiated therapy at different times following infection. We show that a brief exposure to HIV of <1 month does not allow the generation of significant detectable frequencies of HIV-specific CD4+ memory T cells. Patients having prolonged cumulative exposure to high viral load due to therapy failures also demonstrated limited HIV-specific CD4+ T cell responses. In contrast, patients exposed to significant levels of virus for periods ranging from 3 to 18 mo showed brisk and broad HIV-specific CD4 + T cell responses 1 year following the onset of therapy intervention. We also demonstrate that the nadir CD4+ T cell count before therapy initiation correlated positively with the breadth and magnitude of these responses. Our findings indicate that the loss of proliferative HIV-specific CD4+ T cell responses is associated with the systemic progression of the disease and that a brief exposure to HIV does not allow the establishment of detectable frequencies of HIV-specific memory CD4+ T cells.

AB - The impact of exposure to Ag on the development and maintenance of human CD4+ memory T cells in general and HIV infection in particular is partially understood. In this stedy, we measured HIV-specific CD4+ T cell proliferative responses against HIV proteins and derived peptides one year after highly active antiretroviral therapy initiation in 39 HIV-infected patients who initiated therapy at different times following infection. We show that a brief exposure to HIV of <1 month does not allow the generation of significant detectable frequencies of HIV-specific CD4+ memory T cells. Patients having prolonged cumulative exposure to high viral load due to therapy failures also demonstrated limited HIV-specific CD4+ T cell responses. In contrast, patients exposed to significant levels of virus for periods ranging from 3 to 18 mo showed brisk and broad HIV-specific CD4 + T cell responses 1 year following the onset of therapy intervention. We also demonstrate that the nadir CD4+ T cell count before therapy initiation correlated positively with the breadth and magnitude of these responses. Our findings indicate that the loss of proliferative HIV-specific CD4+ T cell responses is associated with the systemic progression of the disease and that a brief exposure to HIV does not allow the establishment of detectable frequencies of HIV-specific memory CD4+ T cells.

UR - http://www.scopus.com/inward/record.url?scp=33846195894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846195894&partnerID=8YFLogxK

M3 - Article

VL - 178

SP - 788

EP - 797

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 2

ER -