The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Thamilarasan Manivasagam; Perumal Subramanian; Ganapathy Suthakar; Musthafa Mohamed Essa

doi:10.32725/jab.2005.024

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Thamilarasan Manivasagam, Perumal Subramanian^*, Ganapathy Suthakar, Musthafa Mohamed Essa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid, reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidant-antioxidant status of the living system. However, the exact mechanism remains to be elucidated.

Original language	English
Pages (from-to)	187-191
Number of pages	5
Journal	Journal of Applied Biomedicine
Volume	3
Issue number	4
DOIs	https://doi.org/10.32725/jab.2005.024
Publication status	Published - Dec 2005
Externally published	Yes

Keywords

Antioxidants
DADS
Hepatocarcinogenesis
Lipid peroxidation

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.32725/jab.2005.024

Cite this

@article{8d03866aa2d243f3a308e90ee312d42e,

title = "The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis",

abstract = "In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid, reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidant-antioxidant status of the living system. However, the exact mechanism remains to be elucidated.",

keywords = "Antioxidants, DADS, Hepatocarcinogenesis, Lipid peroxidation",

author = "Thamilarasan Manivasagam and Perumal Subramanian and Ganapathy Suthakar and Essa, {Musthafa Mohamed}",

year = "2005",

month = dec,

doi = "10.32725/jab.2005.024",

language = "English",

volume = "3",

pages = "187--191",

journal = "Journal of Applied Biomedicine",

issn = "1214-021X",

publisher = "University of South Bohemia",

number = "4",

}

TY - JOUR

T1 - The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

AU - Manivasagam, Thamilarasan

AU - Subramanian, Perumal

AU - Suthakar, Ganapathy

AU - Essa, Musthafa Mohamed

PY - 2005/12

Y1 - 2005/12

N2 - In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid, reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidant-antioxidant status of the living system. However, the exact mechanism remains to be elucidated.

AB - In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid, reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidant-antioxidant status of the living system. However, the exact mechanism remains to be elucidated.

KW - Antioxidants

KW - DADS

KW - Hepatocarcinogenesis

KW - Lipid peroxidation

UR - http://www.scopus.com/inward/record.url?scp=32044441648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32044441648&partnerID=8YFLogxK

U2 - 10.32725/jab.2005.024

DO - 10.32725/jab.2005.024

M3 - Article

AN - SCOPUS:32044441648

SN - 1214-021X

VL - 3

SP - 187

EP - 191

JO - Journal of Applied Biomedicine

JF - Journal of Applied Biomedicine

IS - 4

ER -

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this