The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis

Thamilarasan Manivasagam, Perumal Subramanian, Ganapathy Suthakar, Musthafa Mohamed Essa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the present study we have investigated the anticarcinogenic property of diallyl disulphide (DADS) on hepatic thiobarbituric acid, reactive substances (TBARS) and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase in control, N-nitrosodiethylamine and diallyl disulphide treated rats. The levels of TBARS and activities of SOD and catalase were decreased in NDEA treated rats whereas GSH and GPx tended to increase in carcinogenic rats. Oral administration of DADS (60mg/kg body wt) tends to normalize these variables in liver. This clearly indicates that DADS could possess chemopreventive effects by modulating the oxidant-antioxidant status of the living system. However, the exact mechanism remains to be elucidated.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalJournal of Applied Biomedicine
Volume3
Issue number4
Publication statusPublished - Dec 2005

Fingerprint

Diethylnitrosamine
glutathione peroxidase
Rats
Thiobarbituric Acid Reactive Substances
Glutathione Peroxidase
thiobarbituric acid-reactive substances
Catalase
Superoxide Dismutase
rats
catalase
superoxide dismutase
Antioxidants
antioxidants
liver
Liver
anticarcinogenic activity
Oxidants
oxidants
oral administration
Glutathione

Keywords

  • Antioxidants
  • DADS
  • Hepatocarcinogenesis
  • Lipid peroxidation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)

Cite this

The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis. / Manivasagam, Thamilarasan; Subramanian, Perumal; Suthakar, Ganapathy; Essa, Musthafa Mohamed.

In: Journal of Applied Biomedicine, Vol. 3, No. 4, 12.2005, p. 187-191.

Research output: Contribution to journalArticle

Manivasagam, Thamilarasan ; Subramanian, Perumal ; Suthakar, Ganapathy ; Essa, Musthafa Mohamed. / The chemopreventive effect of diallyl disulphide on N-nitrosodiethylamine induced heptocarcinogenesis. In: Journal of Applied Biomedicine. 2005 ; Vol. 3, No. 4. pp. 187-191.
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