The challenge of west nile virus in Europe: Knowledge gaps and research priorities

A. Rizzoli, M. A. Jiménez-Clavero, L. Barzon, P. Cordioli, J. Figuerola, P. Koraka, B. Martina, A. Moreno, N. Nowotny, N. Pardigon, N. Sanders, S. Ulbert, A. Tenorio

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

West Nile virus (WNV) is continuously spreading across Europe, and other continents, i.e. North and South America and many other regions of the world. Despite the overall sporadic nature of outbreaks with cases of West Nile neuroinvasive disease (WNND) in Europe, the spillover events have increased and the virus has been introduced into new areas. The high genetic diversity of the virus, with remarkable phenotypic variation, and its endemic circulation in several countries, require an intensification of the integrated and multidisciplinary research efforts built under the 7th Framework Programme of the European Union (FP7). It is important to better clarify several aspects of WNV circulation in Europe, including its ecology, genomic diversity, pathogenicity, transmissibility, diagnosis and control options, under different environmental and socio-economic scenarios. Identifying WNV endemic as well as infection-free areas is becoming a need for the development of human vaccines and therapeutics and the application of blood and organs safety regulations. This review, produced as a joint initiative among European experts and based on analysis of 118 scientific papers published between 2004 and 2014, provides the state of knowledge on WNV and highlights the existing knowledge and research gaps that need to be addressed with high priority in Europe and neighbouring countries.

Original languageEnglish
JournalEurosurveillance
Volume20
Issue number20
Publication statusPublished - May 21 2015

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West Nile virus
Research
Blood Safety
Viruses
South America
Human Development
European Union
North America
Ecology
Disease Outbreaks
Virulence
Vaccines
Economics
Infection
Therapeutics

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

Rizzoli, A., Jiménez-Clavero, M. A., Barzon, L., Cordioli, P., Figuerola, J., Koraka, P., ... Tenorio, A. (2015). The challenge of west nile virus in Europe: Knowledge gaps and research priorities. Eurosurveillance, 20(20).

The challenge of west nile virus in Europe : Knowledge gaps and research priorities. / Rizzoli, A.; Jiménez-Clavero, M. A.; Barzon, L.; Cordioli, P.; Figuerola, J.; Koraka, P.; Martina, B.; Moreno, A.; Nowotny, N.; Pardigon, N.; Sanders, N.; Ulbert, S.; Tenorio, A.

In: Eurosurveillance, Vol. 20, No. 20, 21.05.2015.

Research output: Contribution to journalArticle

Rizzoli, A, Jiménez-Clavero, MA, Barzon, L, Cordioli, P, Figuerola, J, Koraka, P, Martina, B, Moreno, A, Nowotny, N, Pardigon, N, Sanders, N, Ulbert, S & Tenorio, A 2015, 'The challenge of west nile virus in Europe: Knowledge gaps and research priorities', Eurosurveillance, vol. 20, no. 20.
Rizzoli A, Jiménez-Clavero MA, Barzon L, Cordioli P, Figuerola J, Koraka P et al. The challenge of west nile virus in Europe: Knowledge gaps and research priorities. Eurosurveillance. 2015 May 21;20(20).
Rizzoli, A. ; Jiménez-Clavero, M. A. ; Barzon, L. ; Cordioli, P. ; Figuerola, J. ; Koraka, P. ; Martina, B. ; Moreno, A. ; Nowotny, N. ; Pardigon, N. ; Sanders, N. ; Ulbert, S. ; Tenorio, A. / The challenge of west nile virus in Europe : Knowledge gaps and research priorities. In: Eurosurveillance. 2015 ; Vol. 20, No. 20.
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