The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes

Peter Von Dadelszen, Sari Kives, Marie France Delisle, R. Douglas Wilson, Ruth Joy, Laurie Ainsworth, Lamya Al Kharusi, Marilynne Oskamp, Jon F R Barrett, Greg Ryan, Dan Farine, P. Gareth R Seaward

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The objective of this study was to evaluate associations between adverse outcomes in twin pregnancies and preterm prelabour rupture of membranes (PPROM). A chart review of 246 consecutive twin pregnancies with confirmed PPROM was conducted. Regression analysis (β [natural log of the odds ratio] and odds ratio [OR]) was performed to identify independent predictors. Two hundred and forty-six twin pregnancies, 492 liveborns, and 20 neonatal deaths. Mean (SD) PPROM gestational age (GA): 31.3 (3.8) wk; delivery GA: 32.0 (3.3) wk. PPROM < 30wk was associated with increased parity (OR: 2.66), and log (admission leukocyte count) (OR: 9.99). Shortened latency was associated with PPROM GA (β = -0.17) and chorioamnionitis (β = 0.95). Neonatal sepsis was predicted by lower delivery GA (OR: 2.04). Adverse perinatal outcomes were protected against by older GA at PPROM (OR 0.53) and shortened latency (OR 0.73). It was concluded that increased leukocytosis and parity implies an infectious aetiology in earlier PPROM. Increased risk for neonatal sepsis at earlier delivery GA is consistent with gestation-dependent fetal immunocompetence. Early PPROM and long latencies were associated with increased adverse perinatal outcomes.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalTwin Research
Volume6
Issue number4
DOIs
Publication statusPublished - Aug 2003

Fingerprint

Chorioamnionitis
Twin Pregnancy
Rupture
Gestational Age
Odds Ratio
Membranes
Infection
Parity
Immunocompetence
Leukocytosis
Leukocyte Count
Regression Analysis
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Genetics(clinical)

Cite this

The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes. / Von Dadelszen, Peter; Kives, Sari; Delisle, Marie France; Wilson, R. Douglas; Joy, Ruth; Ainsworth, Laurie; Al Kharusi, Lamya; Oskamp, Marilynne; Barrett, Jon F R; Ryan, Greg; Farine, Dan; Seaward, P. Gareth R.

In: Twin Research, Vol. 6, No. 4, 08.2003, p. 257-262.

Research output: Contribution to journalArticle

Von Dadelszen, Peter ; Kives, Sari ; Delisle, Marie France ; Wilson, R. Douglas ; Joy, Ruth ; Ainsworth, Laurie ; Al Kharusi, Lamya ; Oskamp, Marilynne ; Barrett, Jon F R ; Ryan, Greg ; Farine, Dan ; Seaward, P. Gareth R. / The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes. In: Twin Research. 2003 ; Vol. 6, No. 4. pp. 257-262.
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