The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats

A. A. Al-Qarawi, H. Abdel-Rahman, B. H. Ali, H. M. Mousa, S. A. El-Mougy

Research output: Contribution to journalArticle

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Abstract

The present work aimed at testing, in a rat model of ethanol-induced gastric ulceration, a local folk medicinal claim that dates are beneficial in gastric ulcers in humans. Aqueous and ethanolic undialyzed and dialyzed extracts from date fruit and pits were given orally to rats at a dose of 4 ml/kg for 14 consecutive days. On the last day of treatment, rats were fasted for 24 h, and were then given ethanol, 80% (1 ml/rat) by gastric intubation to induce gastric ulcer. Rats were killed after 1 h of ethanol exposure, and the incidence and severity of the ulceration were estimated, as well as the concentrations of gastrin in plasma, and histamine and mucus in the gastric mucosa. A single group of rats that were fasted for 24 h, was administered orally with lansoprazole (30 mg/kg), and was given 80% ethanol as above, 8 h thereafter, served as a positive control. The results indicated that the aqueous and ethanolic extracts of the date fruit and, to a lesser extent, date pits, were effective in ameliorating the severity of gastric ulceration and mitigating the ethanol-induced increase in histamine and gastrin concentrations, and the decrease in mucin gastric levels. The ethanolic undialyzed extract was more effective than the rest of the other extracts used. It is postulated that the basis of the gastroprotective action of date extracts may be multi-factorial, and may include an anti-oxidant action.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalJournal of Ethnopharmacology
Volume98
Issue number3
DOIs
Publication statusPublished - Apr 26 2005

Fingerprint

Stomach Ulcer
Ethanol
Stomach
Gastrins
Histamine
Fruit
Gastric Mucins
Lansoprazole
Mucus
Gastric Mucosa
Intubation
Oxidants
Phoeniceae
Incidence

Keywords

  • Dates
  • Ethanol-induced ulcer
  • Gastric histamine
  • Gastrin
  • Lansoprazole
  • Mucin
  • Palmae
  • Phoenix dactylifera L.

ASJC Scopus subject areas

  • Pharmacology

Cite this

The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. / Al-Qarawi, A. A.; Abdel-Rahman, H.; Ali, B. H.; Mousa, H. M.; El-Mougy, S. A.

In: Journal of Ethnopharmacology, Vol. 98, No. 3, 26.04.2005, p. 313-317.

Research output: Contribution to journalArticle

Al-Qarawi, A. A. ; Abdel-Rahman, H. ; Ali, B. H. ; Mousa, H. M. ; El-Mougy, S. A. / The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats. In: Journal of Ethnopharmacology. 2005 ; Vol. 98, No. 3. pp. 313-317.
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