TY - JOUR
T1 - The ameliorative effect of dates (Phoenix dactylifera L.) on ethanol-induced gastric ulcer in rats
AU - Al-Qarawi, A. A.
AU - Abdel-Rahman, H.
AU - Ali, B. H.
AU - Mousa, H. M.
AU - El-Mougy, S. A.
N1 - Funding Information:
This work was supported by funds from the College Research Committee. We thank the Dean of the College of Agriculture and Veterinary Medicine, King Saud University for his interest in this project, and Al Gaseem Date Factory for providing free samples of dates for this study.
PY - 2005/4/26
Y1 - 2005/4/26
N2 - The present work aimed at testing, in a rat model of ethanol-induced gastric ulceration, a local folk medicinal claim that dates are beneficial in gastric ulcers in humans. Aqueous and ethanolic undialyzed and dialyzed extracts from date fruit and pits were given orally to rats at a dose of 4 ml/kg for 14 consecutive days. On the last day of treatment, rats were fasted for 24 h, and were then given ethanol, 80% (1 ml/rat) by gastric intubation to induce gastric ulcer. Rats were killed after 1 h of ethanol exposure, and the incidence and severity of the ulceration were estimated, as well as the concentrations of gastrin in plasma, and histamine and mucus in the gastric mucosa. A single group of rats that were fasted for 24 h, was administered orally with lansoprazole (30 mg/kg), and was given 80% ethanol as above, 8 h thereafter, served as a positive control. The results indicated that the aqueous and ethanolic extracts of the date fruit and, to a lesser extent, date pits, were effective in ameliorating the severity of gastric ulceration and mitigating the ethanol-induced increase in histamine and gastrin concentrations, and the decrease in mucin gastric levels. The ethanolic undialyzed extract was more effective than the rest of the other extracts used. It is postulated that the basis of the gastroprotective action of date extracts may be multi-factorial, and may include an anti-oxidant action.
AB - The present work aimed at testing, in a rat model of ethanol-induced gastric ulceration, a local folk medicinal claim that dates are beneficial in gastric ulcers in humans. Aqueous and ethanolic undialyzed and dialyzed extracts from date fruit and pits were given orally to rats at a dose of 4 ml/kg for 14 consecutive days. On the last day of treatment, rats were fasted for 24 h, and were then given ethanol, 80% (1 ml/rat) by gastric intubation to induce gastric ulcer. Rats were killed after 1 h of ethanol exposure, and the incidence and severity of the ulceration were estimated, as well as the concentrations of gastrin in plasma, and histamine and mucus in the gastric mucosa. A single group of rats that were fasted for 24 h, was administered orally with lansoprazole (30 mg/kg), and was given 80% ethanol as above, 8 h thereafter, served as a positive control. The results indicated that the aqueous and ethanolic extracts of the date fruit and, to a lesser extent, date pits, were effective in ameliorating the severity of gastric ulceration and mitigating the ethanol-induced increase in histamine and gastrin concentrations, and the decrease in mucin gastric levels. The ethanolic undialyzed extract was more effective than the rest of the other extracts used. It is postulated that the basis of the gastroprotective action of date extracts may be multi-factorial, and may include an anti-oxidant action.
KW - Dates
KW - Ethanol-induced ulcer
KW - Gastric histamine
KW - Gastrin
KW - Lansoprazole
KW - Mucin
KW - Palmae
KW - Phoenix dactylifera L.
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U2 - 10.1016/j.jep.2005.01.023
DO - 10.1016/j.jep.2005.01.023
M3 - Article
C2 - 15814265
AN - SCOPUS:16244368818
SN - 0378-8741
VL - 98
SP - 313
EP - 317
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 3
ER -