Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations

Salma M.Z. Al-Kindy*, Khadija Al-Shamalani, Fakhr Eldin O. Suliman, Haidar A.J. Al-Lawati

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb–FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λex = 220 nm and λem = 550 nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25 × 10−6 M of Tb3+, 5.00 × 10−6 M of Et3N and Zn2+ which allows for the determination of 10–800 ppb of FEX in the batch mode with a detection limit of 0.3 ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.

Original languageEnglish
Pages (from-to)2457-2463
Number of pages7
JournalArabian Journal of Chemistry
Issue number8
Publication statusPublished - Dec 2019


  • Drug formulations
  • Fexofenadine
  • Sensitized luminescence
  • Terbium

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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