Abstract
A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.
| Original language | English |
|---|---|
| Journal | Arabian Journal of Chemistry |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2015 |
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Keywords
- Drug formulations
- Fexofenadine
- Sensitized luminescence
- Terbium
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations. / al-kindy, salma; Al-Shamalani, Khadija; Suliman, Fakhr Eldin O.; Al-Lawati, Haidar A.J.
In: Arabian Journal of Chemistry, 01.01.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations
AU - al-kindy, salma
AU - Al-Shamalani, Khadija
AU - Suliman, Fakhr Eldin O.
AU - Al-Lawati, Haidar A.J.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.
AB - A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.
KW - Drug formulations
KW - Fexofenadine
KW - Sensitized luminescence
KW - Terbium
UR - http://www.scopus.com/inward/record.url?scp=85058722920&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058722920&partnerID=8YFLogxK
U2 - 10.1016/j.arabjc.2015.01.016
DO - 10.1016/j.arabjc.2015.01.016
M3 - Article
AN - SCOPUS:85058722920
JO - Arabian Journal of Chemistry
JF - Arabian Journal of Chemistry
SN - 1878-5352
ER -