Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations

salma al-kindy; Khadija Al-Shamalani; Fakhr Eldin O. Suliman; Haidar A.J. Al-Lawati

doi:10.1016/j.arabjc.2015.01.016

Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations

salma al-kindy, Khadija Al-Shamalani, Fakhr Eldin O. Suliman, Haidar A.J. Al-Lawati

Chemistry

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb³⁺) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET₃N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ _ex =220nm and λ _em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10^-6 M of Tb³⁺, 5.00×10^-6 M of Et₃N and Zn²⁺ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.

Original language	English
Journal	Arabian Journal of Chemistry
DOIs	https://doi.org/10.1016/j.arabjc.2015.01.016
Publication status	Accepted/In press - Jan 1 2015

Keywords

Drug formulations
Fexofenadine
Sensitized luminescence
Terbium

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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al-kindy, S., Al-Shamalani, K., Suliman, F. E. O., & Al-Lawati, H. A. J. (Accepted/In press). Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations. Arabian Journal of Chemistry. https://doi.org/10.1016/j.arabjc.2015.01.016

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title = "Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations",

abstract = "A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.",

keywords = "Drug formulations, Fexofenadine, Sensitized luminescence, Terbium",

author = "salma al-kindy and Khadija Al-Shamalani and Suliman, {Fakhr Eldin O.} and Al-Lawati, {Haidar A.J.}",

year = "2015",

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doi = "10.1016/j.arabjc.2015.01.016",

language = "English",

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AU - al-kindy, salma

AU - Al-Shamalani, Khadija

AU - Suliman, Fakhr Eldin O.

AU - Al-Lawati, Haidar A.J.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.

AB - A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.

KW - Drug formulations

KW - Fexofenadine

KW - Sensitized luminescence

KW - Terbium

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