Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations

salma al-kindy, Khadija Al-Shamalani, Fakhr Eldin O. Suliman, Haidar A.J. Al-Lawati

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A sensitive and specific luminescence method for the determination of Fexofenadine (FEX), in pharmaceutical formulations is reported. The method is based on the sensitization of terbium (Tb3+) by complex formation with FEX. The luminescence signal for Tb-FEX complex is greatly enhanced by the addition of triethylamine (ET3N) and zinc nitrate in methanol solution. Monitoring of the signal is accomplished when the instrument is in the phosphorescence mode with the excitation and emission wavelengths set at λ ex =220nm and λ em =550nm respectively. Optimum conditions for the formation of the complex in methanol were 2.25×10-6 M of Tb3+, 5.00×10-6 M of Et3N and Zn2+ which allows for the determination of 10-800ppb of FEX in the batch mode with a detection limit of 0.3ppb. The proposed method was successfully applied for the determination of FEX in pharmaceutical formulations.

Original languageEnglish
JournalArabian Journal of Chemistry
DOIs
Publication statusAccepted/In press - Jan 1 2015

Keywords

  • Drug formulations
  • Fexofenadine
  • Sensitized luminescence
  • Terbium

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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