Temporal variations of lipid peroxidation products, antioxidants and liver marker enzymes in experimental hyperammonemic rats

M. Mohamed Essa, P. Subramanian

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5 Citations (Scopus)

Abstract

Circadian variations of lipid peroxidation products: thiobarbituric acid and reactive substances (TBARS), antioxidants: reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and liver marker enzymes such as transaminases (aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP) and γ-Glutamyl transpeptidase (GGT) in circulation were analysed in control and ammonium chloride (AC) induced (100 mg/kg bodyweight) hyperammonemic rats. Elevated lipid peroxidation and liver marker enzymes (increased mesor of TBARS, AST, ALT, ALP and GGT) associated with decreased activities of antioxidants (decreased mesor of GPx, GSH, SOD and CAT) were found in hyperammonemic rats. Variations in acrophase, amplitude and r values were also found in between the control and hyperammonemic rats. These alterations clearly indicate that temporal liver marker enzymes and redox status are modulated during hyperammonemic conditions, which may also play a crucial role in disease development.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalBiological Rhythm Research
Volume38
Issue number4
DOIs
Publication statusPublished - Aug 2007

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Keywords

  • Antioxidants
  • Circadian
  • Hyperammonemia
  • Liver marker enzymes
  • TBARS

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Physiology

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