Telomerase

Does it have an application in tumour pathology?

A. Grace, M. Mabruk, M. Leader, E. Kay

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The study of ageing and cell senescence has led to the recent interest in telomeres and telomerase. Telomeres are known to play a role in chromosomal replication and each time cells divide these telomeres shorten. Telomere shortening occurs with increased age. Telomerase is the main factor involved in the preservation of telomere length and therefore its activation is mooted to play a role in the immortalisation of cells. It is in this that our interest lies as it is thought that telomerase has a role to play not only in cell immortalisation but also in the development of neoplasia. Much research has been carried out in this exciting field with the aim of elucidating the role telomerase plays in carcinogenesis. This review is an attempt to summarise the recent advances in this area, which is striving to establish if telomerase does indeed have a role to play in either the early diagnosis of carcinoma or as a marker of prognosis.

Original languageEnglish
Pages (from-to)282-285
Number of pages4
JournalCurrent Diagnostic Pathology
Volume6
Issue number4
DOIs
Publication statusPublished - 2000

Fingerprint

Telomerase
Pathology
Telomere
Telomere Shortening
Neoplasms
Cell Aging
Early Diagnosis
Carcinogenesis
Carcinoma
Research

Keywords

  • Pathology
  • Telomerase
  • Tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Telomerase : Does it have an application in tumour pathology? / Grace, A.; Mabruk, M.; Leader, M.; Kay, E.

In: Current Diagnostic Pathology, Vol. 6, No. 4, 2000, p. 282-285.

Research output: Contribution to journalReview article

Grace, A. ; Mabruk, M. ; Leader, M. ; Kay, E. / Telomerase : Does it have an application in tumour pathology?. In: Current Diagnostic Pathology. 2000 ; Vol. 6, No. 4. pp. 282-285.
@article{c6effae84033423495ff620a0d6a628b,
title = "Telomerase: Does it have an application in tumour pathology?",
abstract = "The study of ageing and cell senescence has led to the recent interest in telomeres and telomerase. Telomeres are known to play a role in chromosomal replication and each time cells divide these telomeres shorten. Telomere shortening occurs with increased age. Telomerase is the main factor involved in the preservation of telomere length and therefore its activation is mooted to play a role in the immortalisation of cells. It is in this that our interest lies as it is thought that telomerase has a role to play not only in cell immortalisation but also in the development of neoplasia. Much research has been carried out in this exciting field with the aim of elucidating the role telomerase plays in carcinogenesis. This review is an attempt to summarise the recent advances in this area, which is striving to establish if telomerase does indeed have a role to play in either the early diagnosis of carcinoma or as a marker of prognosis.",
keywords = "Pathology, Telomerase, Tumour",
author = "A. Grace and M. Mabruk and M. Leader and E. Kay",
year = "2000",
doi = "10.1054/cdip.2000.0046",
language = "English",
volume = "6",
pages = "282--285",
journal = "Diagnostic Histopathology",
issn = "1756-2317",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Telomerase

T2 - Does it have an application in tumour pathology?

AU - Grace, A.

AU - Mabruk, M.

AU - Leader, M.

AU - Kay, E.

PY - 2000

Y1 - 2000

N2 - The study of ageing and cell senescence has led to the recent interest in telomeres and telomerase. Telomeres are known to play a role in chromosomal replication and each time cells divide these telomeres shorten. Telomere shortening occurs with increased age. Telomerase is the main factor involved in the preservation of telomere length and therefore its activation is mooted to play a role in the immortalisation of cells. It is in this that our interest lies as it is thought that telomerase has a role to play not only in cell immortalisation but also in the development of neoplasia. Much research has been carried out in this exciting field with the aim of elucidating the role telomerase plays in carcinogenesis. This review is an attempt to summarise the recent advances in this area, which is striving to establish if telomerase does indeed have a role to play in either the early diagnosis of carcinoma or as a marker of prognosis.

AB - The study of ageing and cell senescence has led to the recent interest in telomeres and telomerase. Telomeres are known to play a role in chromosomal replication and each time cells divide these telomeres shorten. Telomere shortening occurs with increased age. Telomerase is the main factor involved in the preservation of telomere length and therefore its activation is mooted to play a role in the immortalisation of cells. It is in this that our interest lies as it is thought that telomerase has a role to play not only in cell immortalisation but also in the development of neoplasia. Much research has been carried out in this exciting field with the aim of elucidating the role telomerase plays in carcinogenesis. This review is an attempt to summarise the recent advances in this area, which is striving to establish if telomerase does indeed have a role to play in either the early diagnosis of carcinoma or as a marker of prognosis.

KW - Pathology

KW - Telomerase

KW - Tumour

UR - http://www.scopus.com/inward/record.url?scp=0034526613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034526613&partnerID=8YFLogxK

U2 - 10.1054/cdip.2000.0046

DO - 10.1054/cdip.2000.0046

M3 - Review article

VL - 6

SP - 282

EP - 285

JO - Diagnostic Histopathology

JF - Diagnostic Histopathology

SN - 1756-2317

IS - 4

ER -