Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer’s disease

Arokiasamy Justin Thenmozhi, Mathiyazahan Dhivyabharathi, Tharsius Raja William Raja, Thamilarasan Manivasagam, Musthafa Mohamed Essa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background/aims: Emblica officinalis is mentioned as a maharasayana in many Ayurvedic texts and promotes intelligence, memory, freedom from disease, longevity, and strength of the senses. The present study has been designed to explore the memory-enhancing effect of the tannoid principles of E. officinalis (EoT) at the biochemical, anatomical, behavioral, and molecular levels against aluminum chloride (AlCl3) induced Alzheimer’s disease (AD) in rats. Aluminum is reported to have an important role in the etiology, pathogenesis, and development of AD. Methods: Male Wistar rats were divided into control, AlCl3 treated, AlCl3 and EoT (50, 100, and 200 mg/kg bw) co-treated, and EoT (200 mg/kg bw) alone treated groups. In control and experimental rats, behavior tests including water maze and open field test, estimation of aluminum, assay of acetylcholinesterase (AChE) activity, and expression of amyloidogenic proteins were performed. Results: Intraperitonial injection of AlCl3 (100 mg/kg bw) for 60 days significantly elevated the concentration of aluminum (Al), activity of AChE and protein expressions of amyloid precursor protein, A-beta1-42, beta-, and gamma-secretases as compared to control group in hippocampus and cortex. Coadministration of EoT orally to AlCl3 rats for 60 days significantly revert back the Al concentration, AChE activity, and A-beta synthesis-related molecules in the studied brain regions. The spatial learning, memory, and locomotor impairments observed in AlCl3 treated rats were significantly attenuated by EoT. Conclusion: Therefore, EoT may be a promising therapy in ameliorating neurotoxicity of aluminum, however further studies are warranted to elucidate the exact mechanism of action of EoT.

Original languageEnglish
Pages (from-to)269-278
Number of pages10
JournalNutritional Neuroscience
Volume19
Issue number6
DOIs
Publication statusPublished - Mar 30 2016

Fingerprint

Phyllanthus emblica
Amyloid
Alzheimer Disease
Aluminum
Pathology
Acetylcholinesterase
Serum Amyloid A Protein
Amyloid Precursor Protein Secretases
Amyloidogenic Proteins
Amyloid beta-Protein Precursor
aluminum chloride
Intelligence
Wistar Rats
Hippocampus
Control Groups
Injections
Water
Brain

Keywords

  • A-beta peptide
  • AChE
  • AlCl
  • Alzheimer’s disease
  • Emblica officinalis
  • Memory
  • Tannoid principles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer’s disease. / Justin Thenmozhi, Arokiasamy; Dhivyabharathi, Mathiyazahan; William Raja, Tharsius Raja; Manivasagam, Thamilarasan; Essa, Musthafa Mohamed.

In: Nutritional Neuroscience, Vol. 19, No. 6, 30.03.2016, p. 269-278.

Research output: Contribution to journalArticle

Justin Thenmozhi, Arokiasamy ; Dhivyabharathi, Mathiyazahan ; William Raja, Tharsius Raja ; Manivasagam, Thamilarasan ; Essa, Musthafa Mohamed. / Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer’s disease. In: Nutritional Neuroscience. 2016 ; Vol. 19, No. 6. pp. 269-278.
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