Taking angiotensin-converting enzyme inhibitors during pregnancy: Is it safe?

Almundher Al-Maawali, Asnat Walfisch, Gideon Koren

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Question One of my 35-year-old pregnant patients has been treated with enalapril for primary hypertension. She learned she was pregnant at 11 weeks' gestation. I read somewhere that angiotensin-converting enzyme (ACE) inhibitors can cause malformations. What advice do you give to Motherisk callers? Answer Most published studies have failed to show an effect of ACE inhibitors on congenital malformations. A recent systematic review and meta-analysis conducted by Motherisk does not suggest increased fetal risk of malformations. However, ACE inhibitors should be avoided in late pregnancy, as they might cause renal failure and acalvaria in the baby.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalCanadian Family Physician
Volume58
Issue number1
Publication statusPublished - Jan 2012

Fingerprint

Angiotensin-Converting Enzyme Inhibitors
Pregnancy
Enalapril
Renal Insufficiency
Meta-Analysis
Hypertension

ASJC Scopus subject areas

  • Family Practice

Cite this

Taking angiotensin-converting enzyme inhibitors during pregnancy : Is it safe? / Al-Maawali, Almundher; Walfisch, Asnat; Koren, Gideon.

In: Canadian Family Physician, Vol. 58, No. 1, 01.2012, p. 49-51.

Research output: Contribution to journalArticle

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