Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand; Younis Baqi; Christa E. Müller

doi:10.1002/jlcr.1942

Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand, Younis Baqi, Christa E. Müller^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A method for the preparation of [Â³H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.1942
Publication status	Published - Jan 2012
Externally published	Yes

Keywords

SV2A protein
epilepsy
high specific activity
levetiracetam
tritium labeling

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.1942

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abstract = "A method for the preparation of [{\^A}3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.",

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AU - Baqi, Younis

AU - Müller, Christa E.

PY - 2012/1

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AB - A method for the preparation of [Â3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

KW - SV2A protein

KW - epilepsy

KW - high specific activity

KW - levetiracetam

KW - tritium labeling

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Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Abstract

Keywords

ASJC Scopus subject areas

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