Abstract
A method for the preparation of [Â 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.
| Original language | English |
|---|---|
| Pages (from-to) | 48-51 |
| Number of pages | 4 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 55 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2012 |
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Keywords
- epilepsy
- high specific activity
- levetiracetam
- SV2A protein
- tritium labeling
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry
- Spectroscopy
- Drug Discovery
- Radiology Nuclear Medicine and imaging
- Biochemistry
Cite this
Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity. / Hildenbrand, Simone; Baqi, Younis; Müller, Christa E.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 55, No. 1, 01.2012, p. 48-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity
AU - Hildenbrand, Simone
AU - Baqi, Younis
AU - Müller, Christa E.
PY - 2012/1
Y1 - 2012/1
N2 - A method for the preparation of [Â 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.
AB - A method for the preparation of [Â 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.
KW - epilepsy
KW - high specific activity
KW - levetiracetam
KW - SV2A protein
KW - tritium labeling
UR - http://www.scopus.com/inward/record.url?scp=84856316140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856316140&partnerID=8YFLogxK
U2 - 10.1002/jlcr.1942
DO - 10.1002/jlcr.1942
M3 - Article
AN - SCOPUS:84856316140
VL - 55
SP - 48
EP - 51
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 1
ER -