Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand; Younis Baqi; Christa E. Müller

doi:10.1002/jlcr.1942

Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand, Younis Baqi, Christa E. Müller^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A method for the preparation of [Â ³H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.1942
Publication status	Published - Jan 2012

Keywords

epilepsy
high specific activity
levetiracetam
SV2A protein
tritium labeling

ASJC Scopus subject areas

Analytical Chemistry
Organic Chemistry
Spectroscopy
Drug Discovery
Radiology Nuclear Medicine and imaging
Biochemistry

Access to Document

10.1002/jlcr.1942

Fingerprint Dive into the research topics of 'Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity'. Together they form a unique fingerprint.

Cite this

@article{8eae78a61639438e908c380514ff1a0a,

title = "Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity",

abstract = "A method for the preparation of [{\^A} 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.",

keywords = "epilepsy, high specific activity, levetiracetam, SV2A protein, tritium labeling",

author = "Simone Hildenbrand and Younis Baqi and M{\"u}ller, {Christa E.}",

year = "2012",

month = jan,

doi = "10.1002/jlcr.1942",

language = "English",

volume = "55",

pages = "48--51",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

AU - Hildenbrand, Simone

AU - Baqi, Younis

AU - Müller, Christa E.

PY - 2012/1

Y1 - 2012/1

N2 - A method for the preparation of [Â 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

AB - A method for the preparation of [Â 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

KW - epilepsy

KW - high specific activity

KW - levetiracetam

KW - SV2A protein

KW - tritium labeling

UR - http://www.scopus.com/inward/record.url?scp=84856316140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856316140&partnerID=8YFLogxK

U2 - 10.1002/jlcr.1942

DO - 10.1002/jlcr.1942

M3 - Article

AN - SCOPUS:84856316140

VL - 55

SP - 48

EP - 51

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 1

ER -