Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand; Younis Baqi; Christa E. Müller

doi:10.1002/jlcr.1942

Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand, Younis Baqi, Christa E. Müller

Chemistry

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A method for the preparation of [Â ³H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.1942
Publication status	Published - Jan 2012

Keywords

epilepsy
high specific activity
levetiracetam
SV2A protein
tritium labeling

ASJC Scopus subject areas

Analytical Chemistry
Organic Chemistry
Spectroscopy
Drug Discovery
Radiology Nuclear Medicine and imaging
Biochemistry

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Hildenbrand, S., Baqi, Y., & Müller, C. E. (2012). Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity. Journal of Labelled Compounds and Radiopharmaceuticals, 55(1), 48-51. https://doi.org/10.1002/jlcr.1942

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