Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand; Younis Baqi; Christa E. Müller

doi:10.1002/jlcr.1942

Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand, Younis Baqi, Christa E. Müller

Chemistry

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A method for the preparation of [Â ³H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

Original language	English
Pages (from-to)	48-51
Number of pages	4
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/jlcr.1942
Publication status	Published - Jan 2012

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Keywords

epilepsy
high specific activity
levetiracetam
SV2A protein
tritium labeling

ASJC Scopus subject areas

Analytical Chemistry
Organic Chemistry
Spectroscopy
Drug Discovery
Radiology Nuclear Medicine and imaging
Biochemistry

Cite this

Hildenbrand, S., Baqi, Y., & Müller, C. E. (2012). Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity. Journal of Labelled Compounds and Radiopharmaceuticals, 55(1), 48-51. https://doi.org/10.1002/jlcr.1942

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Access to Document

10.1002/jlcr.1942