Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity

Simone Hildenbrand, Younis Baqi, Christa E. Müller

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A method for the preparation of [Â 3H]levetiracetam with a high specific activity of 98Ci/mmol (3.6TBq/mmol) is described. The radioligand proved to be highly useful for the labeling of specific levetiracetam binding sites in rat brain membrane preparations.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume55
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

etiracetam
Tritium
Labeling
Rats
Brain
Binding Sites
Membranes

Keywords

  • epilepsy
  • high specific activity
  • levetiracetam
  • SV2A protein
  • tritium labeling

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Drug Discovery
  • Radiology Nuclear Medicine and imaging
  • Biochemistry

Cite this

Synthesis of tritium-labeled levetiracetam ((2S)-2-(2-oxopyrrolidin-1-yl) butanamide) with high specific activity. / Hildenbrand, Simone; Baqi, Younis; Müller, Christa E.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 55, No. 1, 01.2012, p. 48-51.

Research output: Contribution to journalArticle

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