Synthesis of rod-like CeO2 nanoparticles and their application to catalyze the luminal-O2 chemiluminescence reaction used in the determination of oxcarbazepine and ascorbic acid

Mortaza Iranifam, Asghar Haggi, Hossein Akhteh, Mojtaba Amini, Haider A.J. Al Lawati

Research output: Contribution to journalArticlepeer-review

Abstract

Rod-like CeO2 nanoparticles (NPs) were produced by the quick precipitation approach and employed as a catalyzer to increase the chemiluminescence (CL) intensity of the luminol-O2 reaction. The transmission electron microscopy (TEM) images of the CeO2 NPs showed that rod-like particles with the length and diameter about 15 nm and 5 nm, respectively, were produced. Furthermore, pharmaceuticals including oxcarbazepine (OXP) and ascorbic acid (AA) showed an inhibitory effect against the CL intensity such that the more concentration of the pharmaceuticals, the less was the CL intensity. Therefore, the new CeO2 NPs-luminol-O2 CL reaction was developed to determine OXP and AA in the pharmaceutical formulations. It is the first CL method established for the quantification of OXP. The linear dynamic range of this method for OXP was from 6.0 × 10-7 to 6.0 × 10-5 mol L-1 and for AA from 1.0 × 10-6 to 1.0 × 10-4 mol L-1.

Original languageEnglish
Pages (from-to)787-793
Number of pages7
JournalAnalytical Sciences
Volume38
Issue number5
DOIs
Publication statusPublished - May 1 2022
Externally publishedYes

Keywords

  • Ascorbic acid
  • CeO2 nanoparticles
  • Chemiluminescence
  • Luminol
  • Oxcarbazepine

ASJC Scopus subject areas

  • Analytical Chemistry

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