Synthesis of an advanced intermediate of the jatrophane diterpene Pl-4: A dibromide coupling approach

Rita Fürst; Uwe Rinner

doi:10.1021/jo401480t

Synthesis of an advanced intermediate of the jatrophane diterpene Pl-4: A dibromide coupling approach

Rita Fürst, Uwe Rinner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The preparation of an advanced intermediate toward the synthesis of the jatrophane diterpene Pl-4 is described. The key step is a regioselective chelation-controlled lithiation of the (Z)-configured bromide in the corresponding vinyl dibromide precursor. The method outlined within this Article is suitable for the facile access of sterically hindered internal vinyl halides for further coupling reactions.

Original language	English
Pages (from-to)	8748-8758
Number of pages	11
Journal	Journal of Organic Chemistry
Volume	78
Issue number	17
DOIs	https://doi.org/10.1021/jo401480t
Publication status	Published - Sept 6 2013
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo401480t

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abstract = "The preparation of an advanced intermediate toward the synthesis of the jatrophane diterpene Pl-4 is described. The key step is a regioselective chelation-controlled lithiation of the (Z)-configured bromide in the corresponding vinyl dibromide precursor. The method outlined within this Article is suitable for the facile access of sterically hindered internal vinyl halides for further coupling reactions.",

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Synthesis of an advanced intermediate of the jatrophane diterpene Pl-4: A dibromide coupling approach

Abstract

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