Synthesis of an advanced intermediate of the jatrophane diterpene Pl-4: A dibromide coupling approach

Rita Fürst, Uwe Rinner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The preparation of an advanced intermediate toward the synthesis of the jatrophane diterpene Pl-4 is described. The key step is a regioselective chelation-controlled lithiation of the (Z)-configured bromide in the corresponding vinyl dibromide precursor. The method outlined within this Article is suitable for the facile access of sterically hindered internal vinyl halides for further coupling reactions.

Original languageEnglish
Pages (from-to)8748-8758
Number of pages11
JournalJournal of Organic Chemistry
Volume78
Issue number17
DOIs
Publication statusPublished - Sep 6 2013

ASJC Scopus subject areas

  • Organic Chemistry

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