The preparation of an advanced intermediate toward the synthesis of the jatrophane diterpene Pl-4 is described. The key step is a regioselective chelation-controlled lithiation of the (Z)-configured bromide in the corresponding vinyl dibromide precursor. The method outlined within this Article is suitable for the facile access of sterically hindered internal vinyl halides for further coupling reactions.
|Number of pages||11|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - Sept 6 2013|
ASJC Scopus subject areas
- Organic Chemistry