Abstract
A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
| Original language | English |
|---|---|
| Pages (from-to) | 816-819 |
| Number of pages | 4 |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 40 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2005 |
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Keywords
- Antibacterial activity
- Microwave irradiation
- Quinazolines
- Solvent free
ASJC Scopus subject areas
- Molecular Medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials. / Kidwai, M.; Saxena, S.; Khalilur Rahman Khan, M.; Thukral, S. S.
In: European Journal of Medicinal Chemistry, Vol. 40, No. 8, 08.2005, p. 816-819.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials
AU - Kidwai, M.
AU - Saxena, S.
AU - Khalilur Rahman Khan, M.
AU - Thukral, S. S.
PY - 2005/8
Y1 - 2005/8
N2 - A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
AB - A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
KW - Antibacterial activity
KW - Microwave irradiation
KW - Quinazolines
KW - Solvent free
UR - http://www.scopus.com/inward/record.url?scp=23944504818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944504818&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2005.02.009
DO - 10.1016/j.ejmech.2005.02.009
M3 - Article
C2 - 16122583
AN - SCOPUS:23944504818
VL - 40
SP - 816
EP - 819
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
IS - 8
ER -