Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials

M. Kidwai; S. Saxena; M. Khalilur Rahman Khan; S. S. Thukral

doi:10.1016/j.ejmech.2005.02.009

Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials

M. Kidwai, S. Saxena, M. Khalilur Rahman Khan, S. S. Thukral

Microbiology & Immunology

Research output: Contribution to journal › Article

108 Citations (Scopus)

Abstract

A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

Original language	English
Pages (from-to)	816-819
Number of pages	4
Journal	European Journal of Medicinal Chemistry
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.ejmech.2005.02.009
Publication status	Published - Aug 2005

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Keywords

Antibacterial activity
Microwave irradiation
Quinazolines
Solvent free

ASJC Scopus subject areas

Molecular Medicine
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Cite this

Kidwai, M., Saxena, S., Khalilur Rahman Khan, M., & Thukral, S. S. (2005). Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials. European Journal of Medicinal Chemistry, 40(8), 816-819. https://doi.org/10.1016/j.ejmech.2005.02.009

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10.1016/j.ejmech.2005.02.009