Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials

M. Kidwai, S. Saxena, M. Khalilur Rahman Khan, S. S. Thukral

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

Original languageEnglish
Pages (from-to)816-819
Number of pages4
JournalEuropean Journal of Medicinal Chemistry
Volume40
Issue number8
DOIs
Publication statusPublished - Aug 2005

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Thiones
Organic solvents
Escherichia coli
Derivatives
Pseudomonas aeruginosa
Staphylococcus aureus
In Vitro Techniques

Keywords

  • Antibacterial activity
  • Microwave irradiation
  • Quinazolines
  • Solvent free

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials. / Kidwai, M.; Saxena, S.; Khalilur Rahman Khan, M.; Thukral, S. S.

In: European Journal of Medicinal Chemistry, Vol. 40, No. 8, 08.2005, p. 816-819.

Research output: Contribution to journalArticle

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