TY - JOUR
T1 - Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2- one/thione-5-one derivatives and evaluation as antibacterials
AU - Kidwai, M.
AU - Saxena, S.
AU - Khalilur Rahman Khan, M.
AU - Thukral, S. S.
N1 - Funding Information:
The authors (M. Kidwai and S. Saxena) are grateful to University Grants Commission, New Delhi for the financial assistance.
PY - 2005/8
Y1 - 2005/8
N2 - A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
AB - A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
KW - Antibacterial activity
KW - Microwave irradiation
KW - Quinazolines
KW - Solvent free
UR - http://www.scopus.com/inward/record.url?scp=23944504818&partnerID=8YFLogxK
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U2 - 10.1016/j.ejmech.2005.02.009
DO - 10.1016/j.ejmech.2005.02.009
M3 - Article
C2 - 16122583
AN - SCOPUS:23944504818
VL - 40
SP - 816
EP - 819
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
IS - 8
ER -