Abstract
Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
Original language | English |
---|---|
Pages (from-to) | 223-238 |
Number of pages | 16 |
Journal | Nucleosides, Nucleotides and Nucleic Acids |
Volume | 22 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- 5-methoxymethyl-2′-deoxycytidine
- Conformation
- Herpes Simplex Virus
ASJC Scopus subject areas
- Biochemistry
- Genetics