Abstract
Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
| Original language | English |
|---|---|
| Pages (from-to) | 223-238 |
| Number of pages | 16 |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2003 |
Keywords
- 5-methoxymethyl-2′-deoxycytidine
- Conformation
- Herpes Simplex Virus
ASJC Scopus subject areas
- Biochemistry
- Genetics
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Cite this
Zoghaib, W. M., Mannala, S., Gupta, V. S., Tourigny, G., & Reid, R. S. (2003). Synthesis, conformation, and antiviral activity of 5-methoxymethyl-2′-deoxycytidine analogs. Nucleosides, Nucleotides and Nucleic Acids, 22(2), 223-238. https://doi.org/10.1081/NCN-120019532