Abstract
Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
| Original language | English |
|---|---|
| Pages (from-to) | 223-238 |
| Number of pages | 16 |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2003 |
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Keywords
- 5-methoxymethyl-2′-deoxycytidine
- Conformation
- Herpes Simplex Virus
ASJC Scopus subject areas
- Biochemistry
- Genetics
Cite this
Synthesis, conformation, and antiviral activity of 5-methoxymethyl-2′-deoxycytidine analogs. / Zoghaib, Wajdi M.; Mannala, Shajan; Gupta, V. Sagar; Tourigny, Guy; Reid, R. Stephen.
In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 22, No. 2, 2003, p. 223-238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis, conformation, and antiviral activity of 5-methoxymethyl-2′-deoxycytidine analogs
AU - Zoghaib, Wajdi M.
AU - Mannala, Shajan
AU - Gupta, V. Sagar
AU - Tourigny, Guy
AU - Reid, R. Stephen
PY - 2003
Y1 - 2003
N2 - Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
AB - Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
KW - 5-methoxymethyl-2′-deoxycytidine
KW - Conformation
KW - Herpes Simplex Virus
UR - http://www.scopus.com/inward/record.url?scp=0037264166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037264166&partnerID=8YFLogxK
U2 - 10.1081/NCN-120019532
DO - 10.1081/NCN-120019532
M3 - Article
C2 - 12744607
AN - SCOPUS:0037264166
VL - 22
SP - 223
EP - 238
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
SN - 0732-8311
IS - 2
ER -