TY - JOUR
T1 - Synthesis, antitumor activity, and electrochemical behavior of some piperazinyl amidrazones
AU - Abdel-Jalil, Raid Jamil
AU - El Momani, Ehab Q.
AU - Hamad, Muawiah
AU - Voelter, Wolfgang
AU - Mubarak, Mohammad S.
AU - Smith, Bianna H.
AU - Peters, Dennis G.
N1 - Funding Information:
Financial support provided by Hashemite University is gratefully acknowledged. R. J. A.-J. thanks Deutsche Forschungsgemeinschaft (DFG) for a research fellowship for visiting faculty. High-resolution mass analyses were performed in the Indiana University Mass Spectrometry Facility; the HRMS system was purchased with funds provided by the National Institutes of Health grant no. 1S10RR016657-01.
PY - 2010/2
Y1 - 2010/2
N2 - New piperazinyl amidrazones have been synthesized by direct interaction of the corresponding aryl hydrazones with the appropriate piperazine. On the basis of preliminary screening data for these new compounds, the antitumor activity of 1-(4-methylpiperazin-1-yl)-1,2-propan-dione 1-[2-(4-chlorophenyl)hydrazone] and 1-(4-ethylpipera-zin- 1-yl)-1,2-propandione 1-[2-(4-chlorophenyl)hydrazone] was evaluated. Mean 50% growth inhibition (GI50, 50% cell killing (LC50, and total growth inhibition (TGI) for both compounds were calculated on the basis of data obtained from 55 test cell lines. Mean GI 50 is significantly lower for the methylpiperazine derivative (4.81 μM) compared with that of the ethylpiperazine derivative (4.92 μM) (p > 0.01); however, mean TGI is not measurably different (p > 0.1) for both compounds (4.52 and 4.52 μM, respectively). Both compounds exhibit substantial antitumor activity against a number of cell lines at 4 μM concentration. It was found that the methylpiperazine derivative is more potent against leukemia cell lines (mean GI50 = 4.73 μM and mean TGI = 4.36 μM), whereas the ethylpiperazine derivative is more potent against CNS cell lines (GI50 = 4.68 μM and mean TGI = 4.37 μM). Cancers of the breast are least susceptible to methylpiperazine derivative activity compared with all other cell lines (mean GI50 = 4.91 μM). Melanomas and renal cancers are least susceptible to the ethylpiperazine derivative activity as compared with other cancer types (mean GI50 = 5.06 μM). Cyclic voltammetry has been employed to probe the electrochemical oxidation and reduction of the piperazinyl amidrazones at glassy carbon electrodes in dimethylformamide containing tetramethylammonium tetrafluoroborate.
AB - New piperazinyl amidrazones have been synthesized by direct interaction of the corresponding aryl hydrazones with the appropriate piperazine. On the basis of preliminary screening data for these new compounds, the antitumor activity of 1-(4-methylpiperazin-1-yl)-1,2-propan-dione 1-[2-(4-chlorophenyl)hydrazone] and 1-(4-ethylpipera-zin- 1-yl)-1,2-propandione 1-[2-(4-chlorophenyl)hydrazone] was evaluated. Mean 50% growth inhibition (GI50, 50% cell killing (LC50, and total growth inhibition (TGI) for both compounds were calculated on the basis of data obtained from 55 test cell lines. Mean GI 50 is significantly lower for the methylpiperazine derivative (4.81 μM) compared with that of the ethylpiperazine derivative (4.92 μM) (p > 0.01); however, mean TGI is not measurably different (p > 0.1) for both compounds (4.52 and 4.52 μM, respectively). Both compounds exhibit substantial antitumor activity against a number of cell lines at 4 μM concentration. It was found that the methylpiperazine derivative is more potent against leukemia cell lines (mean GI50 = 4.73 μM and mean TGI = 4.36 μM), whereas the ethylpiperazine derivative is more potent against CNS cell lines (GI50 = 4.68 μM and mean TGI = 4.37 μM). Cancers of the breast are least susceptible to methylpiperazine derivative activity compared with all other cell lines (mean GI50 = 4.91 μM). Melanomas and renal cancers are least susceptible to the ethylpiperazine derivative activity as compared with other cancer types (mean GI50 = 5.06 μM). Cyclic voltammetry has been employed to probe the electrochemical oxidation and reduction of the piperazinyl amidrazones at glassy carbon electrodes in dimethylformamide containing tetramethylammonium tetrafluoroborate.
KW - Cancer drugs CNS cancers
KW - Cyclic voltammetry
KW - Piperazinyl amidrazones
UR - http://www.scopus.com/inward/record.url?scp=77952583255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952583255&partnerID=8YFLogxK
U2 - 10.1007/s00706-009-0241-4
DO - 10.1007/s00706-009-0241-4
M3 - Article
AN - SCOPUS:77952583255
SN - 0026-9247
VL - 141
SP - 251
EP - 258
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 2
ER -