Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines

R. J. Abdel-Jalil; R. A. Al-Qawasmeh; W. Voelter; P. Heeg; M. M. El-Abadelah; S. S. Sabri

Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines

R. J. Abdel-Jalil, R. A. Al-Qawasmeh, W. Voelter^*, P. Heeg, M. M. El-Abadelah, S. S. Sabri

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.

Original language	English
Pages (from-to)	1273-1275
Number of pages	3
Journal	Journal of Heterocyclic Chemistry
Volume	37
Issue number	5
Publication status	Published - 2000

ASJC Scopus subject areas

Organic Chemistry

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title = "Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines",

abstract = "The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.",

author = "Abdel-Jalil, {R. J.} and Al-Qawasmeh, {R. A.} and W. Voelter and P. Heeg and El-Abadelah, {M. M.} and Sabri, {S. S.}",

year = "2000",

language = "English",

volume = "37",

pages = "1273--1275",

journal = "Journal of Heterocyclic Chemistry",

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TY - JOUR

T1 - Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines

AU - Abdel-Jalil, R. J.

AU - Al-Qawasmeh, R. A.

AU - Voelter, W.

AU - Heeg, P.

AU - El-Abadelah, M. M.

AU - Sabri, S. S.

PY - 2000

Y1 - 2000

N2 - The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.

AB - The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.

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AN - SCOPUS:0033756483

VL - 37

SP - 1273

EP - 1275

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

SN - 0022-152X

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