Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines

R. J. Abdel-Jalil, R. A. Al-Qawasmeh, W. Voelter, P. Heeg, M. M. El-Abadelah, S. S. Sabri

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.

Original languageEnglish
Pages (from-to)1273-1275
Number of pages3
JournalJournal of Heterocyclic Chemistry
Volume37
Issue number5
Publication statusPublished - 2000

Fingerprint

Quinoxalines
Bioassay
Benzene

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Abdel-Jalil, R. J., Al-Qawasmeh, R. A., Voelter, W., Heeg, P., El-Abadelah, M. M., & Sabri, S. S. (2000). Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines. Journal of Heterocyclic Chemistry, 37(5), 1273-1275.

Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines. / Abdel-Jalil, R. J.; Al-Qawasmeh, R. A.; Voelter, W.; Heeg, P.; El-Abadelah, M. M.; Sabri, S. S.

In: Journal of Heterocyclic Chemistry, Vol. 37, No. 5, 2000, p. 1273-1275.

Research output: Contribution to journalArticle

Abdel-Jalil, RJ, Al-Qawasmeh, RA, Voelter, W, Heeg, P, El-Abadelah, MM & Sabri, SS 2000, 'Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines', Journal of Heterocyclic Chemistry, vol. 37, no. 5, pp. 1273-1275.
Abdel-Jalil, R. J. ; Al-Qawasmeh, R. A. ; Voelter, W. ; Heeg, P. ; El-Abadelah, M. M. ; Sabri, S. S. / Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines. In: Journal of Heterocyclic Chemistry. 2000 ; Vol. 37, No. 5. pp. 1273-1275.
@article{23520354bcec4b4090f6ef07e8247a5e,
title = "Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines",
abstract = "The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.",
author = "Abdel-Jalil, {R. J.} and Al-Qawasmeh, {R. A.} and W. Voelter and P. Heeg and El-Abadelah, {M. M.} and Sabri, {S. S.}",
year = "2000",
language = "English",
volume = "37",
pages = "1273--1275",
journal = "Journal of Heterocyclic Chemistry",
issn = "0022-152X",
publisher = "Heterocorporation",
number = "5",

}

TY - JOUR

T1 - Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines

AU - Abdel-Jalil, R. J.

AU - Al-Qawasmeh, R. A.

AU - Voelter, W.

AU - Heeg, P.

AU - El-Abadelah, M. M.

AU - Sabri, S. S.

PY - 2000

Y1 - 2000

N2 - The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.

AB - The 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)- quinoxalines (3-11) were synthesized for bioassay via reaction of 1.2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzene (2) with the appropriate 1,2-dicarbonyl compounds. However, none of the tested compounds 3-11 showed significant in vitro activity against E. coti ATCC 11229, S. aureus ATCC6538 and C. albicans SATCC 10231.

UR - http://www.scopus.com/inward/record.url?scp=0033756483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033756483&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 1273

EP - 1275

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

SN - 0022-152X

IS - 5

ER -