TY - JOUR
T1 - Synthesis and properties of α-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra®
AU - El-Abadelah, Mustafa M.
AU - Sabri, Salim S.
AU - Khanfar, Monther A.
AU - Voelter, Wolfgang
AU - Abdel-Jalil, Raid J.
AU - Maichle-Mössmer, Cäcilia
AU - Al-Abed, Yousef
PY - 2000/12/1
Y1 - 2000/12/1
N2 - For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra®, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.
AB - For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra®, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.
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M3 - Article
AN - SCOPUS:0034402017
VL - 53
SP - 2643
EP - 2652
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 12
ER -