Synthesis and properties of α-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra®

Mustafa M. El-Abadelah*, Salim S. Sabri, Monther A. Khanfar, Wolfgang Voelter, Raid J. Abdel-Jalil, Cäcilia Maichle-Mössmer, Yousef Al-Abed

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra®, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.

Original languageEnglish
Pages (from-to)2643-2652
Number of pages10
JournalHeterocycles
Volume53
Issue number12
Publication statusPublished - Dec 1 2000

ASJC Scopus subject areas

  • Organic Chemistry

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