Abstract
For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra®, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.
| Original language | English |
|---|---|
| Pages (from-to) | 2643-2652 |
| Number of pages | 10 |
| Journal | Heterocycles |
| Volume | 53 |
| Issue number | 12 |
| Publication status | Published - Dec 1 2000 |
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ASJC Scopus subject areas
- Organic Chemistry
Cite this
Synthesis and properties of α-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra®. / El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Voelter, Wolfgang; Abdel-Jalil, Raid J.; Maichle-Mössmer, Cäcilia; Al-Abed, Yousef.
In: Heterocycles, Vol. 53, No. 12, 01.12.2000, p. 2643-2652.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synthesis and properties of α-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra®
AU - El-Abadelah, Mustafa M.
AU - Sabri, Salim S.
AU - Khanfar, Monther A.
AU - Voelter, Wolfgang
AU - Abdel-Jalil, Raid J.
AU - Maichle-Mössmer, Cäcilia
AU - Al-Abed, Yousef
PY - 2000/12/1
Y1 - 2000/12/1
N2 - For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra®, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.
AB - For structure-activity manipulations, the compound α-thiagra (3), a thiophene bioisostere of viagra®, has been prepared and its X-Ray structure determined. The crystallographic data show that the thiophene and pyrazolo[4,3-d]pyrimidone hetero-ring systems are nearly coplanar by virtue of an adequate intramolecular hydrogen-bond between the pyrimidone NH and the oxygen lone pair of the 3'-ethoxy group.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034402017&partnerID=8YFLogxK
M3 - Article
VL - 53
SP - 2643
EP - 2652
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 12
ER -