Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives

Zafar Saeed Saify; Nousheen Mushtaq; Khalid Mohammed Khan; Shahnaz Perveen; Syed Tasadaque Ali Shah; Raid Jamil Abdel-Jalil; Miriam Fecker; Wolfgang Voelter

doi:10.1248/cpb.53.64

Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives

Zafar Saeed Saify^*, Nousheen Mushtaq, Khalid Mohammed Khan, Shahnaz Perveen, Syed Tasadaque Ali Shah, Raid Jamil Abdel-Jalil, Miriam Fecker, Wolfgang Voelter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A new series of 4-(4′-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.

Original language	English
Pages (from-to)	64-66
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	53
Issue number	1
DOIs	https://doi.org/10.1248/cpb.53.64
Publication status	Published - Jan 2005
Externally published	Yes

Keywords

Activity
Derivative
Piperidine

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.53.64

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abstract = "A new series of 4-(4′-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.",

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AU - Mushtaq, Nousheen

AU - Khan, Khalid Mohammed

AU - Perveen, Shahnaz

AU - Shah, Syed Tasadaque Ali

AU - Abdel-Jalil, Raid Jamil

AU - Fecker, Miriam

AU - Voelter, Wolfgang

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AB - A new series of 4-(4′-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.

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Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives

Abstract

Keywords

ASJC Scopus subject areas

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