Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives

Zafar Saeed Saify, Nousheen Mushtaq, Khalid Mohammed Khan, Shahnaz Perveen, Syed Tasadaque Ali Shah, Raid Jamil Abdel-Jalil, Miriam Fecker, Wolfgang Voelter

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A new series of 4-(4′-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Analgesics
Rats
Pharmacology
Derivatives
Meperidine
Intramuscular Injections
Blood pressure
Tail
Wistar Rats
Nitrogen
Hot Temperature
Body Weight
Blood Pressure
Pharmaceutical Preparations
4-(4'-chlorophenyl)-4-piperidinol

Keywords

  • Activity
  • Derivative
  • Piperidine

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives. / Saify, Zafar Saeed; Mushtaq, Nousheen; Khan, Khalid Mohammed; Perveen, Shahnaz; Shah, Syed Tasadaque Ali; Abdel-Jalil, Raid Jamil; Fecker, Miriam; Voelter, Wolfgang.

In: Chemical and Pharmaceutical Bulletin, Vol. 53, No. 1, 01.2005, p. 64-66.

Research output: Contribution to journalArticle

Saify, Zafar Saeed ; Mushtaq, Nousheen ; Khan, Khalid Mohammed ; Perveen, Shahnaz ; Shah, Syed Tasadaque Ali ; Abdel-Jalil, Raid Jamil ; Fecker, Miriam ; Voelter, Wolfgang. / Synthesis and pharmacological activity of 4-(4′-(chlorophenyl)-4- hydroxypiperidine) derivatives. In: Chemical and Pharmaceutical Bulletin. 2005 ; Vol. 53, No. 1. pp. 64-66.
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