Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl- 1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones

Raid J. Abdel-Jalil, Ehab Al-Momani, Lubna Tahtamooni, H. Juergen MacHulla, Wolfgang Voelter

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)- 4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4-methyl-1-thyl-1-piperazinyl)-2- thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalLetters in Organic Chemistry
Volume7
Issue number5
DOIs
Publication statusPublished - Jul 2010

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Antineoplastic Agents
Cells
Neoplasms
4-hydroxyquinazoline
In Vitro Techniques
3-chloro-4-fluoroaniline

Keywords

  • Anticancer activity
  • Piperazine derivatives
  • Quinazolinone derivatives

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

Cite this

Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl- 1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones. / Abdel-Jalil, Raid J.; Al-Momani, Ehab; Tahtamooni, Lubna; MacHulla, H. Juergen; Voelter, Wolfgang.

In: Letters in Organic Chemistry, Vol. 7, No. 5, 07.2010, p. 360-366.

Research output: Contribution to journalArticle

Abdel-Jalil, Raid J. ; Al-Momani, Ehab ; Tahtamooni, Lubna ; MacHulla, H. Juergen ; Voelter, Wolfgang. / Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl- 1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones. In: Letters in Organic Chemistry. 2010 ; Vol. 7, No. 5. pp. 360-366.
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