TY - JOUR
T1 - Synthesis and In-Vitro Antitumor Activity of Selected 7-Fluoro-6-(4-methyl- 1-piperazinyl)-2-(thiosubstituted)-4(3H)-quinazolinones
AU - Abdel-Jalil, Raid J.
AU - Al-Momani, Ehab
AU - Tahtamooni, Lubna
AU - MacHulla, H. Juergen
AU - Voelter, Wolfgang
PY - 2010/7
Y1 - 2010/7
N2 - A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)- 4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4-methyl-1-thyl-1-piperazinyl)-2- thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.
AB - A new series of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-(thiosubstituted)- 4(3H)-quinazolinones was synthesized as potential antitumor agents by multi-step synthesis starting with the commercially available 3-chloro-4-fluoroaniline. The most promising candidate, 7-fluoro-6-(4-methyl-1-thyl-1-piperazinyl)-2- thioethyl-4(3H)-quinazolinone (5a), was screened in 60 human cancer cells by NCI.
KW - Anticancer activity
KW - Piperazine derivatives
KW - Quinazolinone derivatives
UR - http://www.scopus.com/inward/record.url?scp=77955942427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955942427&partnerID=8YFLogxK
U2 - 10.2174/157017810791514751
DO - 10.2174/157017810791514751
M3 - Article
AN - SCOPUS:77955942427
SN - 1570-1786
VL - 7
SP - 360
EP - 366
JO - Letters in Organic Chemistry
JF - Letters in Organic Chemistry
IS - 5
ER -
